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公开(公告)号：US09062089B2
公开(公告)日：2015-06-23
申请号：US14234024
申请日：2012-07-21
IPC分类号： C07H23/00 , A61K31/7135 , C07H5/08 , C07F15/00 , A61K45/06
CPC分类号： C07H5/10 , A61K31/7135 , A61K45/06 , C07F15/0046 , C07H5/08 , C07H23/00 , Y02A50/411
摘要： The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
摘要翻译： 本发明提供式（I）的新型钌化合物：或其盐，异构体，水合物或溶剂合物或其组合; 其中E，R 1，R 2，R 3，R 4，R 5，X 1和X 2如本文所定义，及其药物组合物。 还提供了使用和治疗的方法。 已经发现这些化合物可用于治疗疟疾感染。 此类化合物还可用于治疗炎性病症，例如急性肺损伤和急性呼吸窘迫综合征，其任选地可能与疟疾感染相关。
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公开(公告)号：US20140219996A1
公开(公告)日：2014-08-07
申请号：US14234024
申请日：2012-07-20
IPC分类号： C07H23/00 , A61K45/06 , A61K31/7135
CPC分类号： C07H5/10 , A61K31/7135 , A61K45/06 , C07F15/0046 , C07H5/08 , C07H23/00 , Y02A50/411
摘要： The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
摘要翻译： 本发明提供式（I）的新型钌化合物：或其盐，异构体，水合物或溶剂合物或其组合; 其中E，R 1，R 2，R 3，R 4，R 5，X 1和X 2如本文所定义，及其药物组合物。 还提供了使用和治疗的方法。 已经发现这些化合物可用于治疗疟疾感染。 此类化合物还可用于治疗炎性病症，例如急性肺损伤和急性呼吸窘迫综合征，其任选地可能与疟疾感染相关。
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3.发明授权Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists 失效预防肝细胞生长因子拮抗剂对人类疟疾感染的方法公开(公告)号：US07670631B2
公开(公告)日：2010-03-02
申请号：US10795456
申请日：2004-03-09
IPC分类号： A61K36/48
CPC分类号： C07K16/22 , A61K2039/505 , Y02A50/412
摘要： A method for the prevention of infection of humans by plasmodium parasites is provided. The method consists of the application of compounds that interfere with the infection of hepatocytes by Plasmodium viax.
摘要翻译： 提供了一种通过疟原虫寄生虫预防人感染的方法。 该方法包括通过疟原虫毒素干扰肝细胞感染的化合物的应用。
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4.发明申请Use of Inhibitors of Scavenger Receptor Class Proteins for the Treatment of Infectious Diseases 审中-公开使用清除剂受体类蛋白抑制剂治疗传染病公开(公告)号：US20090324580A1
公开(公告)日：2009-12-31
申请号：US12281438
申请日：2007-03-09
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/02 , A61K31/7088 , A61K31/397 , A61K31/55 , A61K31/5365 , A61K31/505 , A61K31/4439 , A61K31/428 , A61K31/416 , A61K31/403 , A61K31/352 , A61K31/175 , A61K31/17 , A61K31/16 , A61K31/155
CPC分类号： G01N33/5047 , A61K31/122 , A61K31/137 , A61K31/15 , A61K31/155 , A61K31/165 , A61K31/17 , A61K31/35 , A61K31/397 , A61K31/4706 , A61K31/49 , A61K31/505 , A61K31/536 , A61K31/65 , G01N33/5067 , G01N33/56905 , G01N2333/445 , G01N2500/00 , Y02A50/409 , Y02A50/411 , Y02A50/414 , A61K2300/00
摘要： The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
摘要翻译： 本发明涉及清道夫受体类蛋白质抑制剂，特别是ScarB1在制备用于治疗和/或预防感染的药物中的应用，涉及肝细胞和/或造血细胞，特别是疟疾。
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5.发明授权公开(公告)号：US08507546B2
公开(公告)日：2013-08-13
申请号：US13548777
申请日：2012-07-13
CPC分类号： G01N33/5047 , A61K31/122 , A61K31/137 , A61K31/15 , A61K31/155 , A61K31/165 , A61K31/17 , A61K31/35 , A61K31/397 , A61K31/4706 , A61K31/49 , A61K31/505 , A61K31/536 , A61K31/65 , G01N33/5067 , G01N33/56905 , G01N2333/445 , G01N2500/00 , Y02A50/409 , Y02A50/411 , Y02A50/414 , A61K2300/00
摘要： The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
摘要翻译： 本发明涉及清道夫受体类蛋白质抑制剂，特别是ScarB1在制备用于治疗和/或预防感染的药物中的应用，涉及肝细胞和/或造血细胞，特别是疟疾。
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