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公开(公告)号：US09637556B2
公开(公告)日：2017-05-02
申请号：US14052451
申请日：2013-10-11
Applicant: ANAPTYSBIO, INC.
Inventor： Peter M. Bowers , Andrew B. Cubitt , Robert A. Horlick
CPC classification number: C07K16/461 , C07K16/00 , C07K16/22 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/92 , C40B50/06
Abstract: This invention relates to methods for the generation of humanized antibodies, particularly a humanized antibody heavy chain protein and a humanized antibody light chain protein. The method comprises using cells that express or can be induced to express Activation Induced Cytidine Deaminase (AID).
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公开(公告)号：US11999783B2
公开(公告)日：2024-06-04
申请号：US17071046
申请日：2020-10-15
Applicant: AnaptysBio, Inc.
Inventor： Robert A. Horlick , David J. King , Andrew John McKnight
IPC: A61K39/395 , C07K16/24
CPC classification number: C07K16/244 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
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公开(公告)号：US20180346562A1
公开(公告)日：2018-12-06
申请号：US16042476
申请日：2018-07-23
Applicant: AnaptysBio, Inc.
Inventor： Robert A. Horlick , David J. King , Andrew John McKnight
IPC: C07K16/24
CPC classification number: C07K16/244 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
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公开(公告)号：US10059764B2
公开(公告)日：2018-08-28
申请号：US15110724
申请日：2015-01-09
Applicant: AnaptysBio, Inc.
Inventor： Robert A. Horlick , David J. King , Andrew John McKnight
IPC: A61K39/395 , C07K16/24
CPC classification number: C07K16/244 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
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公开(公告)号：US20160333090A1
公开(公告)日：2016-11-17
申请号：US15110724
申请日：2015-01-09
Applicant: Robert A. HORLICK , David J. KING , Andrew John MCKNIGHT , ANAPTYSBIO,INC.
Inventor： Robert A. Horlick , David J. King , Andrew John MCKNIGHT
IPC: C07K16/24
CPC classification number: C07K16/244 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
Abstract translation: 本发明涉及分离的免疫球蛋白重链多肽和结合白细胞介素-33（IL-33）的分离的免疫球蛋白轻链多肽。 本发明提供了包含上述免疫球蛋白重链多肽和免疫球蛋白轻链多肽的IL-33-结合剂。 本发明还提供了使用IL-33-结合剂治疗对IL-33抑制有反应的哺乳动物疾病的相关载体，组合物和方法。
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Patent Agency Ranking
公开(公告)号：US20240294631A1
公开(公告)日：2024-09-05
申请号：US18651131
申请日：2024-04-30
Applicant: AnaptysBio, Inc.
Inventor： Robert A. Horlick , David J. King , Andrew John McKnight
IPC: C07K16/24
CPC classification number: C07K16/244 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
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公开(公告)号：US20170158762A1
公开(公告)日：2017-06-08
申请号：US15115574
申请日：2015-01-27
Applicant: AnaptysBio, Inc.
Inventor： Helen Toni Jun , Robert A. Horlick , David J. King
IPC: C07K16/28
CPC classification number: C07K16/28 , C07K16/2851 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to Discoidin Domain Receptor Family, Member 1 (DDR1). The invention provides a DDR1-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the DDR1-binding agent to treat a DDR1-mediated disease.
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公开(公告)号：US09260533B2
公开(公告)日：2016-02-16
申请号：US14181096
申请日：2014-02-14
Applicant: AnaptysBio, Inc.
Inventor： Peter M. Bowers , Andrew B. Cubitt , Robert A. Horlick
CPC classification number: C07K16/461 , C07K16/00 , C07K16/22 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/92 , C40B50/06
Abstract: This invention relates to methods for the generation of humanized antibodies, particularly a humanized antibody heavy chain protein and a humanized antibody light chain protein. The method comprises using cells that express or can be induced to express Activation Induced Cytidine Deaminase (AID).
Abstract translation: 本发明涉及产生人源化抗体，特别是人源化抗体重链蛋白质和人源化抗体轻链蛋白质的方法。 该方法包括使用表达或可诱导表达激活诱导的胞苷脱氨酶（AID）的细胞。
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公开(公告)号：US20150118226A1
公开(公告)日：2015-04-30
申请号：US14587479
申请日：2014-12-31
Applicant: ANAPTYSBIO, INC.
Inventor： David J. King , Peter Bowers , Robert A. Horlick , Tamlyn Yee Neben
IPC: C07K16/22
CPC classification number: C07K16/22 , C07H21/04 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that binds to Nerve Growth Factor (NGF). The invention provides an NGF-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides vectors, compositions, and methods of using the NGF-binding agent to treat an NGF-mediated disease.
Abstract translation: 本发明涉及分离的免疫球蛋白重链多肽和结合神经生长因子（NGF）的分离的免疫球蛋白轻链多肽。 本发明提供了包含上述免疫球蛋白重链多肽和免疫球蛋白轻链多肽的NGF结合剂。 本发明还提供使用NGF结合剂治疗NGF介导的疾病的载体，组合物和方法。
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公开(公告)号：US20210040198A1
公开(公告)日：2021-02-11
申请号：US17071046
申请日：2020-10-15
Applicant: AnaptysBio, Inc.
Inventor： Robert A. Horlick , David J. King , Andrew John McKnight
IPC: C07K16/24
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
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