公开(公告)号：US07647102B2

公开(公告)日：2010-01-12

申请号：US11283401

申请日：2005-11-18

申请人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

发明人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

IPC分类号： A61N1/00

CPC分类号： A61N1/3621 ,  A61N1/3627 ,  A61N1/39 ,  A61N1/3962

摘要： A cardiac contractility modulating (CCM) device (30) includes an anti-arrhythmic therapy unit (38) for detecting a cardiac arrhythmia in a heart (2) of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit (40) capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device (30) includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

摘要翻译： 心脏收缩力调节（CCM）装置（30）包括抗心律失常治疗单元（38），用于基于处理与心脏感测到的心脏活动相关的电信号来检测患者心脏（2）中的心律不齐，以及 用于向心脏递送抗心律失常药物。 该装置包括能够向心脏递送心脏收缩调节（CCM）信号以调节一部分心脏的收缩力的心脏收缩力调节（CCM）单元（40）。 该装置可以向抗心律失常治疗单元提供与将CCM信号递送到心脏相关联的信号。 控制信号可以用于防止CCM信号与心律不齐的检测的干扰。 设备（30）包括电源。 该装置可以是可植入装置或非植入装置。 该装置还可以包括起搏单元。

公开(公告)号：US06993385B1

公开(公告)日：2006-01-31

申请号：US10111515

申请日：2000-10-24

申请人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

发明人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

IPC分类号： A61N1/18

CPC分类号： A61N1/3621 ,  A61N1/3627 ,  A61N1/39 ,  A61N1/3962

摘要： A cardiac contractility modulating (CCM) device includes an anti-arrhythmic therapy unit for detecting a cardiac arrhythmia in a heart of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating unit capable of delivering cardiac contractility modulating signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

摘要翻译： 心脏收缩力调节（CCM）装置包括抗心律失常治疗单元，用于基于处理与心脏感测到的心脏活动相关的电信号，以及用于向心脏递送抗心律失常疗法来检测患者心脏中的心律失常 。 该装置包括心脏收缩力调节单元，其能够向心脏输送心脏收缩调节信号，以调节一部分心脏的收缩性。 该装置可以向抗心律失常治疗单元提供与将CCM信号递送到心脏相关联的信号。 控制信号可以用于防止CCM信号与心律不齐的检测的干扰。 该装置包括电源。 该装置可以是可植入装置或非植入装置。 该装置还可以包括起搏单元。

公开(公告)号：US07027863B1

公开(公告)日：2006-04-11

申请号：US10111516

申请日：2000-10-25

申请人： David Prutchi ,  Nissim Darvish ,  Andre G. Routh ,  Edward Haluska ,  Ziv Belsky

发明人： David Prutchi ,  Nissim Darvish ,  Andre G. Routh ,  Edward Haluska ,  Ziv Belsky

IPC分类号： A61N1/39

CPC分类号： A61N1/39 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/3962

摘要： A multi-modal cardiotherapy device (100) includes an anti-arrhythmic unit (118) for delivering multiple types of anti-arrhythmic therapy to a heart, a cardiac contractility modulating unit (108) for delivering cardiac contractility modulating signals to the heart, and for applying anti-arrhythmic cardiac contractility modulating signal therapy to the heart, one or more sensing units (112) for sensing electrical signals related to electrical activity of the heart to provide an output signal, one or more detecting units (116) operatively connected to the sensing unit(s) (112) for detecting in the output signal cardiac events of the heart, a controller unit (106) operatively connected to the anti-arrhythmic unit (118), the cardiac contractility modulating unit (108) and the detecting unit(s) (116). The controller unit (106) processes the output of the detecting unit(s) (116) to detect a cardiac arrhythmia or indications of a possible arrhythmia in the heart and controls the application of anti-arrhythmic therapy, anti-arrhythmic cardiac contractility modulating signal therapy, and cardiac contractility modulating therapy to the heart. The device may be an implantable device or a non-implantable device. The device (100) may also include a pacing unit (102). Methods are disclosed for using the device for delivering multi-modal cardiotherapy to the heart.

摘要翻译： 多模式心脏治疗装置（100）包括用于向心脏递送多种类型的抗心律失常治疗的抗心律不齐装置（118），用于将心脏收缩调节信号输送到心脏的心脏收缩力调节单元（108），以及 用于向心脏施加抗心律失常心脏收缩调节信号治疗的一个或多个感测单元（112），用于感测与心脏的电活动相关的电信号以提供输出信号;一个或多个检测单元（116），其可操作地连接到 用于在输出信号中检测心脏心脏事件的感测单元（112），可操作地连接到抗心律失调单元（118）的心脏收缩力调节单元（108）和检测器 单位（116）。 控制器单元（106）处理检测单元（116）的输出以检测心脏心律失常或心脏中可能的心律不齐的指征，并控制抗心律不齐治疗，抗心律失常心肌收缩调节信号的应用 治疗和心脏收缩力调节治疗心脏。 该装置可以是可植入装置或非植入装置。 设备（100）还可以包括起搏单元（102）。 公开了使用用于向心脏递送多模式心脏治疗的装置的方法。

公开(公告)号：US06597952B1

公开(公告)日：2003-07-22

申请号：US09782347

申请日：2001-02-12

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61N1362

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions.

摘要翻译： 一种用于在可患者组织控制装置中的警报时间窗口的参数设置方法，所述可激发组织控制装置在患者的心脏的多个不同心脏状态下工作。 该方法包括向所述可兴奋的组织控制装置提供包括多组警报时间窗参数的一组数据。 每套窗口参数与识别不同心脏状况之一的多个心脏病状定义参数的不同的值集合唯一地相关联。 每组窗口参数包括至少一组可用于获得警报窗口的开始时间点和结束时间点的定时参数。 窗口参数的集合通过在不同的心脏状况下处理来自同一患者的多个心跳的数据收集会话内收集的数据来获得。

公开(公告)号：US06459928B2

公开(公告)日：2002-10-01

申请号：US09768968

申请日：2001-01-24

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A01B50402

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.

公开(公告)号：US06233487B1

公开(公告)日：2001-05-15

申请号：US09338649

申请日：1999-06-23

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61N1362

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions. The methods updates for each current beat cycle the values of a plurality of cardiac condition defining variables corresponding to said cardiac condition defining parameters, automatically selects a current set of alert time window parameters based on the current values of the cardiac condition defining variables, starts and terminates the alert time window based on the time of detecting a first depolarization event at a first cardiac site, detects within the duration of the alert window a second depolarization event at a second cardiac site, and triggers the delivery of a delayed non-excitatory excitable tissue control signal at the second cardiac site based on the time of detection of the second depolarization event. The different cardiac conditions include different beat cycle lengths, and may include beats which are or are not influenced by prior application of ETC signals to the heart and, where relevant, naturally and artificially paced beats. The alert window parameters may include an event detection sensitivity level parameter. Implantable and external devices are describe which are adapted for implementing the disclosed method.

公开(公告)号：US06223072B1

公开(公告)日：2001-04-24

申请号：US09328068

申请日：1999-06-08

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61B50456

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.

公开(公告)号：US5749900A

公开(公告)日：1998-05-12

申请号：US570727

申请日：1995-12-11

申请人： Edward A. Schroeppel ,  David Prutchi ,  Andre G. Routh

发明人： Edward A. Schroeppel ,  David Prutchi ,  Andre G. Routh

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/3627 ,  A61N1/36592

摘要： A method and apparatus for evaluating heart rate variability of the heart of a person in order to forecast a cardiac event. A cardiac stimulator receives heart beat signals from the heart and determines a measurement of heart rate variability based on statistical data derived from the heart beat signals and sensing data derived from a sensor. This measurement of heart rate variability is compared with previously stored heart rate variability zones defining normal and abnormal heart rate variability. These zones are modifiable after the occurrence of a cardiac event. Once a cardiac event is detected, a pathway is computed which extends from a generally normal heart rate variability condition to an abnormal heart rate variability condition. Subsequent measurements of heart rate variability are compared with this pathway. Selective therapy regimes are initiated depending on the measurement of heart rate variability.

公开(公告)号：US6144878A

公开(公告)日：2000-11-07

申请号：US477979

申请日：2000-01-05

申请人： Edward A. Schroeppel ,  David Prutchi ,  Andre G. Routh

发明人： Edward A. Schroeppel ,  David Prutchi ,  Andre G. Routh

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/39 ,  A61B5/04

CPC分类号： A61B5/02405 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/3962 ,  A61N1/3627 ,  A61N1/36592

摘要： A method and apparatus for evaluating heart rate variability of the heart of a person in order to forecast a cardiac event. A cardiac stimulator receives heart beat signals from the heart and determines a measurement of heart rate variability based on statistical data derived from the heart beat signals and sensing data derived from a sensor. This measurement of heart rate variability is compared with previously stored heart rate variability zones defining normal and abnormal heart rate variability. These zones are modifiable after the occurrence of a cardiac event. Once a cardiac event is detected, a pathway is computed which extends from a generally normal heart rate variability condition to an abnormal heart rate variability condition. Subsequent measurements of heart rate variability are compared with this pathway. Selective therapy regimes are initiated depending on the measurement of heart rate variability.

公开(公告)号：US6035233A

公开(公告)日：2000-03-07

申请号：US5194

申请日：1998-01-09

申请人： Edward A. Schroeppel ,  David Prutchi ,  Andre G. Routh

发明人： Edward A. Schroeppel ,  David Prutchi ,  Andre G. Routh

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/39 ,  A61B5/04

CPC分类号： A61B5/02405 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/3962 ,  A61N1/3627 ,  A61N1/36592

摘要： A method and apparatus for evaluating heart rate variability of the heart of a person in order to forecast a cardiac event. A cardiac stimulator receives heart beat signals from the heart and determines a measurement of heart rate variability based on statistical data derived from the heart beat signals and sensing data derived from a sensor. This measurement of heart rate variability is compared with previously stored heart rate variability zones defining normal and abnormal heart rate variability. These zones are modifiable after the occurrence of a cardiac event. Once a cardiac event is detected, a pathway is computed which extends from a generally normal heart rate variability condition to an abnormal heart rate variability condition. Subsequent measurements of heart rate variability are compared with this pathway. Selective therapy regimes are initiated depending on the measurement of heart rate variability.

摘要翻译： 一种用于评估人的心脏心率变异性以便预测心脏事件的方法和装置。 心脏刺激器从心脏接收心跳信号，并且基于从心跳信号导出的统计数据和从传感器导出的感测数据来确定心率变异性的测量。 将心率变异性的这种测量与定义正常和异常心率变异性的先前存储的心率变异区进行比较。 发生心脏事件后，这些区域可以修改。 一旦检测到心脏事件，则计算从通常正常的心率变异性状态延伸到异常心率变异性状况的途径。 随后将心率变异性测量与该途径进行比较。 选择性治疗方案根据心率变异性的测量开始。