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公开(公告)号：US08508744B2
公开(公告)日：2013-08-13
申请号：US13379073
申请日：2010-06-18
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/274 , G01N21/554
摘要： A SPR sensing method comprising the steps of: providing a SPR sensor comprising a SPR supporting sensor surface and contacting a sample to be analysed with the sensor surface. At least one resonance condition at said SPR supporting sensor surface is monitored by illuminating the sensor surface with an SPR exciting test light beam and sensing the reflected or transmitted test light beam. Additionally, the sensor surface is illuminated with a reference light beam under conditions selected so as not to excite SPR at said sensor surface and sensing the intensity of the reflected or transmitted reference light beam. At least one property of the reflected or transmitted test light beam is determined taking into account the sensed intensity of the reflected or transmitted reference light beam.
摘要翻译： SPR感测方法包括以下步骤：提供SPR传感器，其包括SPR支持的传感器表面并使待分析的样品与传感器表面接触。 通过用SPR激发测试光束照射传感器表面并感测反射或透射的测试光束来监测在所述SPR支撑传感器表面处的至少一个共振条件。 此外，传感器表面在被选择的条件下用参考光束照射，以便不在所述传感器表面处激发SPR并感测被反射或透射的参考光束的强度。 考虑反射或透射的参考光束的感测强度来确定反射或透射的测试光束的至少一个特性。
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公开(公告)号：US20120120401A1
公开(公告)日：2012-05-17
申请号：US13379073
申请日：2010-06-18
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/274 , G01N21/554
摘要： A SPR sensing method comprising the steps of: providing a SPR sensor comprising a SPR supporting sensor surface and contacting a sample to be analysed with the sensor surface. At least one resonance condition at said SPR supporting sensor surface is monitored by illuminating the sensor surface with an SPR exciting test light beam and sensing the reflected or transmitted test light beam. Additionally, the sensor surface is illuminated with a reference light beam under conditions selected so as not to excite SPR at said sensor surface and sensing the intensity of the reflected or transmitted reference light beam. At least one property of the reflected or transmitted test light beam is determined taking into account the sensed intensity of the reflected or transmitted reference light beam.
摘要翻译： SPR感测方法包括以下步骤：提供SPR传感器，其包括SPR支持的传感器表面并使待分析的样品与传感器表面接触。 通过用SPR激发测试光束照射传感器表面并感测反射或透射的测试光束来监测在所述SPR支撑传感器表面处的至少一个共振条件。 此外，传感器表面在被选择的条件下用参考光束照射，以便不在所述传感器表面处激发SPR并且感测被反射或透射的参考光束的强度。 考虑反射或透射的参考光束的感测强度来确定反射或透射的测试光束的至少一个特性。
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公开(公告)号：US20140134714A1
公开(公告)日：2014-05-15
申请号：US14232359
申请日：2012-05-31
申请人： Andrea Valsesia , Franco Marabelli , Silvia Giudicatti , Gerardo Marchesini , François Rossi , Pascal Colpo
发明人： Andrea Valsesia , Franco Marabelli , Silvia Giudicatti , Gerardo Marchesini , François Rossi , Pascal Colpo
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , G01N21/554
摘要： A sensor device comprises a dielectric substrate (52); and a metal layer (53) on the substrate (52) with at least one array of cavities (54) therein and adapted to support L-SPR, each of the cavities (54) in the metal layer (53) having an opening (56) and a closed bottom (58) and widening from opening to bottom. A bed of dielectric material (62) is provided over the bottom (58) of each cavity (54) to reduce its apparent depth, the bed surface (62) being functionalized to bind to receptor moieties (64). This sensor device is particularly designed for SPR detection, but can be used in other detection techniques.
摘要翻译： 传感器装置包括电介质基片（52）; 和在衬底（52）上的金属层（53），其中具有至少一个空腔阵列（54）并且适于支撑L-SPR，金属层（53）中的每个空腔（54）具有开口 56）和封闭的底部（58），并从开口到底部变宽。 介电材料床（62）设置在每个空腔（54）的底部（58）上方以减小其表观深度，床表面（62）被功能化以结合受体部分（64）。 该传感器设备特别设计用于SPR检测，但可用于其他检测技术。
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公开(公告)号：US09395363B2
公开(公告)日：2016-07-19
申请号：US14232359
申请日：2012-05-31
申请人： Andrea Valsesia , Franco Marabelli , Silvia Giudicatti , Gerardo Marchesini , François Rossi , Pascal Colpo
发明人： Andrea Valsesia , Franco Marabelli , Silvia Giudicatti , Gerardo Marchesini , François Rossi , Pascal Colpo
IPC分类号： G01N33/543 , G01N21/552
CPC分类号： G01N33/54373 , G01N21/554
摘要： A sensor device comprises a dielectric substrate (52); and a metal layer (53) on the substrate (52) with at least one array of cavities (54) therein and adapted to support L-SPR, each of the cavities (54) in the metal layer (53) having an opening (56) and a closed bottom (58) and widening from opening to bottom. A bed of dielectric material (62) is provided over the bottom (58) of each cavity (54) to reduce its apparent depth, the bed surface (62) being functionalized to bind to receptor moieties (64). This sensor device is particularly designed for SPR detection, but can be used in other detection techniques.
摘要翻译： 传感器装置包括电介质基片（52）; 和在衬底（52）上的金属层（53），其中具有至少一个空腔阵列（54）并且适于支撑L-SPR，金属层（53）中的每个空腔（54）具有开口 56）和封闭的底部（58），并从开口到底部变宽。 介电材料床（62）设置在每个空腔（54）的底部（58）上方以减小其表观深度，床表面（62）被功能化以结合受体部分（64）。 该传感器设备特别设计用于SPR检测，但可用于其他检测技术。
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