公开(公告)号：US20060111570A1

公开(公告)日：2006-05-25

申请号：US11249172

申请日：2005-10-11

申请人： Andres Francesch ,  Carolina Fernandez ,  Jose Chicharro ,  Pilar Gallego ,  Maria Zarzuelo ,  Ignacio Manzanares ,  Marta Perez ,  Carmen Cuevas ,  Maria Martin ,  Simon Munt

发明人： Andres Francesch ,  Carolina Fernandez ,  Jose Chicharro ,  Pilar Gallego ,  Maria Zarzuelo ,  Ignacio Manzanares ,  Marta Perez ,  Carmen Cuevas ,  Maria Martin ,  Simon Munt

IPC分类号： C07D498/14

CPC分类号： C07D471/18 ,  C07D471/22 ,  C07D491/22 ,  C07D515/22

摘要： Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxyl, di-6,8-en-5-one fused ring compound. After formation of the 1,4 brige, C-18 protection is removed before spiroamine introduction.

摘要翻译： 提供了制备具有式（XIV）的稠环结构的化合物的方法。 这些产品包括海马神经氨酸，并具有螺胺-1,4-桥。 涉及使用1-不稳定的10-羟基，18-保护的羟基，二-6,8-烯-5-酮稠环化合物形成1,4桥的方法。 形成1,4格氏之后，在引入螺环胺之前，C-18保护被去除。

公开(公告)号：US20060019960A1

公开(公告)日：2006-01-26

申请号：US11045595

申请日：2005-01-26

申请人： Ignacio Manzanares ,  Maria Martin ,  Alberto Rodriguez ,  Simon Munt ,  Carmen Cuevas ,  Marta Perez

发明人： Ignacio Manzanares ,  Maria Martin ,  Alberto Rodriguez ,  Simon Munt ,  Carmen Cuevas ,  Marta Perez

IPC分类号： A61K31/498 ,  C07D491/14

CPC分类号： C07D491/18 ,  C07D471/18 ,  C07D471/22 ,  C07D491/22 ,  C07D497/22

摘要： Antitumor compounds have the five membered fused ring ecteinascidin structure of the formula (XIV). The present compounds lack a 1,4-bridging group as found in the ecteinascidins. They have at the C-1 position a substituent selected from an optionally protected or derivatised aminomethylene group or an optionally protected or derivatised hydroxymethylene group.

摘要翻译： 抗肿瘤化合物具有式（XIV）的五元稠环环虫苷结构。 本发明化合物缺乏在ecteinascidins中发现的1,4桥连基团。 它们在C-1位具有选自任选保护或衍生的氨基亚甲基或任选保护或衍生的羟基亚甲基的取代基。

公开(公告)号：US20080051407A1

公开(公告)日：2008-02-28

申请号：US11645356

申请日：2006-12-22

申请人： Ignacio Manzanares ,  Maria Martin ,  Alberto Rodriguez ,  Simon Munt ,  Carmen Cuevas ,  Marta Perez

发明人： Ignacio Manzanares ,  Maria Martin ,  Alberto Rodriguez ,  Simon Munt ,  Carmen Cuevas ,  Marta Perez

IPC分类号： A61K31/496 ,  A61P35/00 ,  C07D241/36

CPC分类号： C07D491/18 ,  C07D471/18 ,  C07D471/22 ,  C07D491/22 ,  C07D497/22

摘要： Antitumor compounds have the five membered fused ring ecteinascidin structure of the formula (XIV). The present compounds lack a 1,4-bridging group as found in the ecteinascidins. They have at the C-1 position a substituent selected from an optionally protected or derivatised aminomethylene group or an optionally protected or derivatised hydroxymethylene group.

摘要翻译： 抗肿瘤化合物具有式（XIV）的五元稠环环虫苷结构。 本发明化合物缺乏在ecteinascidins中发现的1,4桥连基团。 它们在C-1位具有选自任选保护或衍生的氨基亚甲基或任选保护或衍生的羟基亚甲基的取代基。

公开(公告)号：US20070233534A1

公开(公告)日：2007-10-04

申请号：US11712669

申请日：2007-03-01

申请人： Edward Martin ,  Maria Martin

发明人： Edward Martin ,  Maria Martin

IPC分类号： G06Q10/00 ,  G06Q30/00 ,  G06F17/50

CPC分类号： G06Q10/06 ,  G06Q10/103

摘要： A project management system and method are provided wherein projects can be managed easily and with minimal manual data entry. Project management software, embodying the project management system of the present invention, can run on a computer network or user workstation, without requiring a dedicated host server. The project management system of the present invention provides at least one graphical interface, to permit a user to easily create and/or edit a project, tasks, subprojects and milestones, using the mouse or other pointer device. A resource window can be provided, conveniently and consistently located in all main views of the system, to assist the user in efficiently operating the project management system. Further, projects can be automatically updated without repetitive data entry, using data entered once by the user performing a task.

摘要翻译： 提供了项目管理系统和方法，其中可以容易地管理项目并且以最少的手动数据输入。 体现本发明的项目管理系统的项目管理软件可以在计算机网络或用户工作站上运行，而不需要专用的主机服务器。 本发明的项目管理系统提供至少一个图形界面，以允许用户使用鼠标或其它指针装置容易地创建和/或编辑项目，任务，子项目和里程碑。 可以提供资源窗口，方便和一致地位于系统的所有主视图中，以帮助用户有效地操作项目管理系统。 此外，可以使用执行任务的用户一次输入的数据，自动更新项目而不重复输入数据。

公开(公告)号：USD695483S1

公开(公告)日：2013-12-10

申请号：US29442316

申请日：2013-02-05

申请人： Maria Martin

设计人： Maria Martin

公开(公告)号：US07498937B2

公开(公告)日：2009-03-03

申请号：US11594381

申请日：2006-11-08

申请人： Errol Martin ,  Maria Martin

发明人： Errol Martin ,  Maria Martin

IPC分类号： G08B1/08

CPC分类号： G08B21/0288 ,  G08B21/0291

摘要： An A-Z locator for transmitting and receiving signals and a portable device for transmitting and receiving signals. A position identifier for communicating with a Global Positioning System to determine a location of the A-Z Locator. A transmitter for transmitting a signal to the portable device. A GPS converter for converting such location to a communication signal. A receiver for receiving vocal communication having an electrical connection to a vocal converter for converting the vocal communication to a signal. Pushbuttons for initiating a signal for communication to the portable device and activating such vocal receiver. A transmitter for transmitting a communication signal. A receiver for receiving a communication signal. A converter for converting the signal to vocal communication. An amplifier for amplification of such vocal communication. A speaker for emitting such vocal communication. Pushbuttons for initiating a signal to be communicated to a predetermined location and for activating the vocal receiver.

摘要翻译： 用于发送和接收信号的A-Z定位器和用于发送和接收信号的便携式设备。 用于与全球定位系统通信以确定A-Z定位器的位置的位置标识符。 一种用于将信号发送到便携式设备的发射机。 一种用于将这种位置转换为通信信号的GPS转换器。 一种用于接收具有与声音转换器的电连接以将声音通信转换成信号的声音通信的接收机。 用于启动用于与便携式设备通信的信号并激活这种声音接收器的按钮。 一种用于发送通信信号的发射机。 一种用于接收通信信号的接收机。 A转换器，用于将信号转换为声音通信。 用于放大这种声音通信的放大器。 用于发出这种声音通信的扬声器。 用于启动要被传送到预定位置并激活声音接收器的信号的按钮。

公开(公告)号：US20070192748A1

公开(公告)日：2007-08-16

申请号：US11650806

申请日：2007-01-08

申请人： Edward Martin ,  Maria Martin

发明人： Edward Martin ,  Maria Martin

IPC分类号： G06F3/048 ,  G06F17/00

CPC分类号： G06F3/0486 ,  G06Q10/06

摘要： A project management system and method are provided wherein projects can be managed easily and with minimal manual data entry. Project management software, embodying the project management system of the present invention, can run on a computer network or user workstation, without requiring a dedicated host server. The project management system of the present invention provides at least one graphical interface, to permit a user to easily create and/or edit a project, tasks, subprojects and milestones, using the mouse or other pointer device. A resource window can be provided, conveniently and consistently located in all main views of the system, to assist the user in efficiently operating the project management system. Further, projects can be automatically updated without repetitive data entry, using data entered once by the user performing a task.

公开(公告)号：US20070187442A1

公开(公告)日：2007-08-16

申请号：US11706095

申请日：2007-02-13

申请人： Errol Martin ,  Maria Martin

发明人： Errol Martin ,  Maria Martin

IPC分类号： A45F3/16 ,  A45F5/00

CPC分类号： A01K7/00 ,  A01K29/00 ,  A45F3/047 ,  A45F3/20 ,  A45F2003/166

摘要： An apparatus for use with a pet. The apparatus comprises a backpack having a predetermined size and made of a predetermined material designed to fit on a dog's back. There is a waterproof container member made of a predetermined material and disposed within the backpack for storing water. A first means is disposed on the waterproof container for filling the container and a hose member is connected to the container member for dispensing such one of water and ice water whenever it is needed. A harness means is engageable with the backpack for securing the backpack to a dog's torso.

摘要翻译： 与宠物一起使用的装置。 该装置包括具有预定尺寸并由设计成适合于狗背部的预定材料制成的背包。 存在由预定材料制成并设置在用于储存水的背包内的防水容器构件。 第一装置设置在用于填充容器的防水容器上，并且软管构件连接到容器构件，用于在需要时分配水和冰水中的一种。 绑带装置可与背包接合，用于将背包固定到狗的躯干上。

公开(公告)号：US20070103293A1

公开(公告)日：2007-05-10

申请号：US11594381

申请日：2006-11-08

申请人： Errol Martin ,  Maria Martin

发明人： Errol Martin ,  Maria Martin

IPC分类号： G08B1/08

CPC分类号： G08B21/0288 ,  G08B21/0291

摘要： An A-Z locator for transmitting and receiving signals and a portable device for transmitting and receiving signals. A position identifier for communicating with a Global Positioning System to determine a location of the A-Z Locator. A transmitter for transmitting a signal to the portable device. A GPS converter for converting such location to a communication signal. A receiver for receiving vocal communication having an electrical connection to a vocal converter for converting the vocal communication to a signal. Pushbuttons for initiating a signal for communication to the portable device and activating such vocal receiver. A transmitter for transmitting a communication signal. A receiver for receiving a communication signal. A converter for converting the signal to vocal communication. An amplifier for amplification of such vocal communication. A speaker for emitting such vocal communication. Pushbuttons for initiating a signal to be communicated to a predetermined location and for activating the vocal receiver.

摘要翻译： 用于发送和接收信号的A-Z定位器和用于发送和接收信号的便携式设备。 用于与全球定位系统通信以确定A-Z定位器的位置的位置标识符。 一种用于将信号发送到便携式设备的发射机。 一种用于将这种位置转换为通信信号的GPS转换器。 一种用于接收具有与声音转换器的电连接以将声音通信转换成信号的声音通信的接收机。 用于启动用于与便携式设备通信的信号并激活这种声音接收器的按钮。 一种用于发送通信信号的发射机。 一种用于接收通信信号的接收机。 A转换器，用于将信号转换为声音通信。 用于放大这种声音通信的放大器。 用于发出这种声音通信的扬声器。 用于启动要被传送到预定位置并激活声音接收器的信号的按钮。