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1.发明授权Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof 有权人类Janus Kinase 2（JAK2）的晶体结构及其用途公开(公告)号：US07593820B2
公开(公告)日：2009-09-22
申请号：US11248478
申请日：2005-10-11
申请人： Andrew Frederick Wilks , Christopher John Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Leanne Styles
发明人： Andrew Frederick Wilks , Christopher John Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Leanne Styles
CPC分类号： C07D491/04 , C07D471/04 , C07K2299/00 , C12N9/1205 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
摘要翻译： 本发明涉及人类Janus Kinase 2（JAK2）结构域的X射线晶体学研究。 更具体地，涉及与抑制剂结合的JAK2激酶结构域的晶体结构。 本发明还涉及晶体和相关结构信息用于选择和筛选与JAK2和相关蛋白相互作用的化合物以及可用于治疗由不适当的JAK2活性介导的疾病的化合物。
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公开(公告)号：US20070136005A1
公开(公告)日：2007-06-14
申请号：US11650004
申请日：2007-01-04
申请人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
发明人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
IPC分类号： G06F19/00
CPC分类号： C12N9/1205 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
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公开(公告)号：US20070129896A1
公开(公告)日：2007-06-07
申请号：US11650063
申请日：2007-01-04
申请人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
发明人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
IPC分类号： G06F19/00
CPC分类号： C12N9/1205 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
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公开(公告)号：US20070276607A1
公开(公告)日：2007-11-29
申请号：US11649951
申请日：2007-01-04
申请人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
发明人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
CPC分类号： C12N9/1205 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
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公开(公告)号：US20070136006A1
公开(公告)日：2007-06-14
申请号：US11650613
申请日：2007-01-04
申请人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
发明人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
CPC分类号： C12N9/1205 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
摘要翻译： 本发明涉及JAK2激酶结构域的X射线晶体学研究。 更具体地，涉及与抑制剂结合的JAK2激酶结构域的晶体结构。 本发明还涉及晶体和相关结构信息用于选择和筛选与JAK2和相关蛋白相互作用的化合物以及可用于治疗由不适当的JAK2活性介导的疾病的化合物。
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公开(公告)号：US20070129895A1
公开(公告)日：2007-06-07
申请号：US11650062
申请日：2007-01-04
申请人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
发明人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
IPC分类号： G06F19/00
CPC分类号： C12N9/1205 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
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公开(公告)号：US20070128709A1
公开(公告)日：2007-06-07
申请号：US11248478
申请日：2005-10-11
申请人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
发明人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
CPC分类号： C07D491/04 , C07D471/04 , C07K2299/00 , C12N9/1205 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
摘要翻译： 本发明涉及人类Janus Kinase 2（JAK2）结构域的X射线晶体学研究。 更具体地，涉及与抑制剂结合的JAK2激酶结构域的晶体结构。 本发明还涉及晶体和相关结构信息用于选择和筛选与JAK2和相关蛋白相互作用的化合物以及可用于治疗由不适当的JAK2活性介导的疾病的化合物。
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