公开(公告)号：US20170046484A1

公开(公告)日：2017-02-16

申请号：US15237249

申请日：2016-08-15

申请人： Andrew J. Buckler ,  Keith A. Moulton ,  Mary Buckler ,  Larry Martell ,  David S. Paik ,  Xiaonan Ma ,  Samantha St. Pierre

发明人： Andrew J. Buckler ,  Keith A. Moulton ,  Mary Buckler ,  Larry Martell ,  David S. Paik ,  Xiaonan Ma ,  Samantha St. Pierre

IPC分类号： G06F19/00 ,  G06F17/30 ,  G06F21/62

摘要： Methods and systems for making image-derived information available by performing analyses with semantic annotations accessible using semantic web technology for personalized medicine and discovery science are disclosed. Individual cases are identified according to an identification scheme. Targets for image analysis for each case are characterized in order to support tracking of a given anatomy, suspected pathology, confirmed pathology, or medical intervention at one or more timepoints. Access information to one or more medical images of each target at each one of the one or more timepoints is provided and stored. One or more levels of image-derived analysis is obtained and stored, the image derived analysis including at least one of imaging features, measured quantities, phenotypic descriptions, or predictions relative to said one case. A semantic search ability accesses across stored data items, for imaging or non-imaging associated data, according to concepts in an ontology according to relationships, without requiring the queries to be defined beforehand. By accessing predetermined data services, queries from the knowledge base are formed in order to collect data sets. The data sets can be used to test a hypothesis, the hypothesis related to supporting tracking of the given anatomy, the suspected pathology, the confirmed pathology, or the medical intervention.

摘要翻译： 公开了通过使用可用于个性化医学和发现科学的语义网技术访问的语义注释进行分析来制作图像衍生信息的方法和系统。 根据识别方案识别个案。 每个病例的图像分析目标的特征在于支持在一个或多个时间点跟踪给定的解剖结构，疑似病理学，确认的病理学或医学干预。 提供并存储在一个或多个时间点中的每一个处访问每个目标的一个或多个医学图像的信息。 获得并存储图像衍生分析的一个或多个级别，所述图像衍生分析包括相对于所述一种情况的成像特征，测量量，表型描述或预测中的至少一种。 根据关系，根据本体的概念，语义搜索能力跨存储的数据项访问，用于成像或非成像相关联的数据，而不需要事先定义查询。 通过访问预定的数据服务，形成来自知识库的查询以便收集数据集。 数据集可用于测试假设，与支持跟踪给定解剖结构相关的假设，可疑病理学，确诊病理学或医学干预。

公开(公告)号：US10176408B2

公开(公告)日：2019-01-08

申请号：US14959732

申请日：2015-12-04

申请人： David S. Paik ,  Andrew J. Buckler ,  Kjell Johnson ,  Xiaonan Ma ,  Keith A. Moulton

发明人： David S. Paik ,  Andrew J. Buckler ,  Kjell Johnson ,  Xiaonan Ma ,  Keith A. Moulton

IPC分类号： G06K9/00 ,  G06K9/62

摘要： Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

公开(公告)号：US20180330477A1

公开(公告)日：2018-11-15

申请号：US15874474

申请日：2018-01-18

申请人： David S. Paik ,  Andrew J. Buckler ,  Kjell Johnson ,  Xiaonan Ma ,  Keith A. Moulton

发明人： David S. Paik ,  Andrew J. Buckler ,  Kjell Johnson ,  Xiaonan Ma ,  Keith A. Moulton

IPC分类号： G06T5/00 ,  G06T7/136 ,  G06T7/11 ,  G06T7/194 ,  G06T7/00 ,  G06K9/46

摘要： The present disclosure provides for improved image analysis via novel deblurring and segmentation techniques of image data. These techniques advantageously account for and incorporate segmentation of biological analytes into a deblurring process for an image. Thus, the deblurring of the image may advantageously be optimized for enabling identification and quantitative analysis of one or more biological analytes based on underlying biological models for those analytes. The techniques described herein provide for significant improvements in the image deblurring and segmentation process which reduces signal noise and improves the accuracy of the image. In particular, the system and methods described herein advantageously utilize unique optimization and tissue characteristics image models which are informed by the underlying biology being analyzed, (for example by a biological model for the analytes). This provides for targeted deblurring and segmentation which is optimized for the applied image analytics.

公开(公告)号：US20170046839A1

公开(公告)日：2017-02-16

申请号：US14959732

申请日：2015-12-04

申请人： David S. Paik ,  Andrew J. Buckler ,  Kjell Johnson ,  Xiaonan Ma ,  Keith A. Moulton

发明人： David S. Paik ,  Andrew J. Buckler ,  Kjell Johnson ,  Xiaonan Ma ,  Keith A. Moulton

IPC分类号： G06T7/00

CPC分类号： G06K9/6296 ,  A61B6/032 ,  A61B6/504 ,  G06K9/00147

摘要： Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

摘要翻译： 本文介绍了利用定量成像分析病变的系统和方法。 有利地，本公开的系统和方法利用分层分析框架，其从成像数据识别和定量生物学特性/分析物，然后基于量化的生物学特性/分析物来鉴定和表征一种或多种病理学。 使用成像检查潜在生物学作为评估病理学的中介的这种分层方法提供了许多分析和处理优势，其优于被配置为直接确定和表征基础成像数据的病理学的系统和方法。

公开(公告)号：US20100030729A1

公开(公告)日：2010-02-04

申请号：US12182063

申请日：2008-07-29

申请人： Windsor Wee Sun Hsu ,  Xiaonan Ma

发明人： Windsor Wee Sun Hsu ,  Xiaonan Ma

IPC分类号： G06F17/30 ,  G06F12/02

CPC分类号： G06F17/30

摘要： The invention provides a method and system for managing data access. The method includes receiving a request for accessing a file, determining a type of the received request that corresponds to an access pattern based on history of many files, marking the request based on the type of request to identify the request as a candidate to be part of a sequential scan for accessing files in a sequential order, and processing the request based on the marking to throttle access of the file in the case of a potential ongoing erroneously requested sequential scan.

摘要翻译： 本发明提供了一种用于管理数据访问的方法和系统。 该方法包括接收访问文件的请求，基于许多文件的历史来确定与访问模式相对应的接收到的请求的类型，基于请求的类型来标识请求以将请求标识为候选者 用于按顺序访问文件的顺序扫描，以及在潜在的正在进行的错误请求的顺序扫描的情况下，基于标记来处理该请求以节省文件的访问。

公开(公告)号：US08055635B2

公开(公告)日：2011-11-08

申请号：US12134089

申请日：2008-06-05

申请人： Windsor Wee Sun Hsu ,  Xiaonan Ma

发明人： Windsor Wee Sun Hsu ,  Xiaonan Ma

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： G06F17/30477 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935

摘要： A correctness verification system receives a query, executes the query using a query logic, and produces a query result. The query result comprises data records that satisfy the query, data verification objects associated with the data records, index segments accessed during the execution of the query, index verification objects associated with the index segments, and the query. The system transfers the query result to a verification system. The verification system verifies correctness of the query result by executing the query using the query logic. The verification system uses the data verification objects to verify integrity of the data objects, uses the index verification objects to verify the integrity of the index segments, and uses the index verification objects and the data verification objects to verify the completeness of the query result.

摘要翻译： 正确性验证系统接收查询，使用查询逻辑执行查询，并产生查询结果。 查询结果包括满足查询的数据记录，与数据记录相关联的数据验证对象，在执行查询期间访问的索引段，与索引段相关联的索引验证对象和查询。 系统将查询结果传送到验证系统。 验证系统通过使用查询逻辑执行查询来验证查询结果的正确性。 验证系统使用数据验证对象来验证数据对象的完整性，使用索引验证对象来验证索引段的完整性，并使用索引验证对象和数据验证对象来验证查询结果的完整性。

公开(公告)号：US07570560B2

公开(公告)日：2009-08-04

申请号：US12019247

申请日：2008-01-24

申请人： Windsor Wee Sun Hsu ,  Xiaonan Ma

发明人： Windsor Wee Sun Hsu ,  Xiaonan Ma

IPC分类号： G11B7/00

CPC分类号： H04L9/0836 ,  H04L9/0894

摘要： Files are encrypted and stored on a WORM media device along with their encryption keys, the binary values of which are stored as a combination of written and unwritten sectors in a key storage portion of the media. To shred a file, the associated key is destroyed simply by writing into the unwritten sectors that are associated with the key.

摘要翻译： 文件被加密并存储在WORM媒体设备上以及它们的加密密钥，其二进制值作为写入和未写入扇区的组合存储在媒体的密钥存储部分中。 为了切割文件，关联的密钥只需通过写入与密钥相关联的未写入的扇区来销毁。

公开(公告)号：US20090049086A1

公开(公告)日：2009-02-19

申请号：US12255201

申请日：2008-10-21

申请人： Windsor Wee Sun Hsu ,  Xiaonan Ma

发明人： Windsor Wee Sun Hsu ,  Xiaonan Ma

IPC分类号： G06F17/30

CPC分类号： G06F21/805 ,  Y10S707/99931 ,  Y10S707/99945 ,  Y10S707/99948

摘要： An object storage system provides a storage object to support index structures, logs, and audit trails in WORM storage. The storage object includes a mutable object, an immutable object, or an appendable object. For each storage object, the system maintains an indication of type, such as mutable, immutable, or appendable object type. A mutable object can be arbitrarily modified, an immutable object cannot be modified, and the contents of the appendable object cannot be modified but can be appended with new data. Appended data becomes immutable. The system enables a protection level represented by the object type to be upgraded but not downgraded. Consequently, data committed to be immutable cannot be changed by changing the type of the storage object.

摘要翻译： 对象存储系统提供一个存储对象来支持WORM存储中的索引结构，日志和审计跟踪。 存储对象包括可变对象，不可变对象或可追加对象。 对于每个存储对象，系统维护类型的指示，例如可变的，不可变的或可追加的对象类型。 可变对象可以任意修改，不可修改的对象不能被修改，并且可追加对象的内容不能被修改，而是可以附加新的数据。 附加数据变得不可变。 该系统使得由对象类型表示的保护级别能够升级但不降级。 因此，不能通过更改存储对象的类型来改变承诺为不可变的数据。

公开(公告)号：US20080270372A1

公开(公告)日：2008-10-30

申请号：US12134089

申请日：2008-06-05

申请人： Windsor Wee Sun HSU ,  Xiaonan Ma

发明人： Windsor Wee Sun HSU ,  Xiaonan Ma

IPC分类号： G06F17/30

CPC分类号： G06F17/30477 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935

摘要： A correctness verification system receives a query, executes the query using a query logic, and produces a query result. The query result comprises data records that satisfy the query, data verification objects associated with the data records, index segments accessed during the execution of the query, index verification objects associated with the index segments, and the query. The system transfers the query result to a verification system. The verification system verifies correctness of the query result by executing the query using the query logic. The verification system uses the data verification objects to verify integrity of the data objects, uses the index verification objects to verify the integrity of the index segments, and uses the index verification objects and the data verification objects to verify the completeness of the query result.

公开(公告)号：US20090041253A1

公开(公告)日：2009-02-12

申请号：US11835646

申请日：2007-08-08

申请人： Hong Chen ,  Windsor Wee Sun Hsu ,  Xiaonan Ma

发明人： Hong Chen ,  Windsor Wee Sun Hsu ,  Xiaonan Ma

IPC分类号： H04L9/08

CPC分类号： H04L9/3247 ,  H04L9/321 ,  H04L2209/30 ,  H04L2209/38

摘要： The present invention relates to a method for proving the correctness of a query result produced by a data publisher while preserving the privacy of the query result. The method comprises delivering a public key of a public key/private key pair from a data owner to a client and delivering data and cryptographic metadata to at least one data publisher, wherein the metadata is associated both with the data and the public key of the public key/private key pair. The method further comprises receiving a query from the client, returning a query result and a verification object from the data publisher to the client in response to the query, and verifying the correctness of the query result, wherein the correctness of the query result is verified utilizing the verification object and the public key.

摘要翻译： 本发明涉及一种用于证明由数据发布者产生的查询结果的正确性的方法，同时保持查询结果的隐私。 该方法包括将公共密钥/私钥对的公开密钥从数据所有者传递到客户端，并将数据和加密元数据传递给至少一个数据发布者，其中元数据与数据和公开密钥相关联 公钥/私钥对。 该方法还包括从客户端接收查询，响应于查询将查询结果和验证对象从数据发布者返回到客户端，以及验证查询结果的正确性，其中验证查询结果的正确性 利用验证对象和公钥。