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公开(公告)号:US07635701B2
公开(公告)日:2009-12-22
申请号:US10524470
申请日:2003-08-19
申请人: Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty, legal representative , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
发明人: Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
IPC分类号: C07D239/42 , A61K31/505
CPC分类号: C07D239/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12
摘要: The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译: 本发明涉及新颖的嘧啶衍生物,含有这些化合物的药物组合物及其在治疗疾病尤其是疼痛中的用途,该疾病是由大麻素受体的活性的增加或减少直接或间接引起的。
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公开(公告)号:US20100041654A1
公开(公告)日:2010-02-18
申请号:US12582861
申请日:2009-10-21
申请人: Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
发明人: Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , William Leonard Mitchell , Alan Naylor , Derek Anthony Rawlings , Brian Peter Slingsby , Andrew Richard Whittington
IPC分类号: C07D239/42 , A61K31/505 , A61K31/5377 , C07D413/02 , A61K31/496 , C07D401/02 , A61P29/00 , A61P19/02 , A61P19/10
CPC分类号: C07D239/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12
摘要: This relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译: 这涉及新颖的嘧啶衍生物,含有这些化合物的药物组合物及其在治疗疾病尤其是疼痛中的用途,该疾病是由大麻素受体的活性的增加或减少直接或间接引起的。
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3.Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine 审中-公开
标题翻译: Cb2调节剂和Pde4抑制剂的组合用于医学公开(公告)号:US20080132505A1
公开(公告)日:2008-06-05
申请号:US10597527
申请日:2005-02-01
申请人: Andrew James Brown , Helen Elizabeht Connor , Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , Karamjit Singh Jandu , Richard Graham Knowles , William Leonard Mitchell , Alan Naylor , Celestine Theresa O'Shaughnessy , Giovanni Palombi , Derek Anthony Rawlings , Brian Peter Slingsby , Catherine Jane Tralau-Stewart , Andrew Richard Whittington , Richard Alexander Williamson
发明人: Andrew James Brown , Helen Elizabeht Connor , Andrew John Eatherton , Gerard Martin Paul Giblin , Richard Howard Green , Jennifer Margaret Doughty , Karamjit Singh Jandu , Richard Graham Knowles , William Leonard Mitchell , Alan Naylor , Celestine Theresa O'Shaughnessy , Giovanni Palombi , Derek Anthony Rawlings , Brian Peter Slingsby , Catherine Jane Tralau-Stewart , Andrew Richard Whittington , Richard Alexander Williamson
IPC分类号: A61K31/505 , A61K31/5377 , A61K31/4406 , A61K31/44 , A61P37/00 , A61P29/00 , A61P25/00 , A61P11/00
CPC分类号: A61K31/505 , A61K2300/00
摘要: Combination of one or more CB2 modulators and one or more PDE4 inhibitors, and method of treating conditions which are mediated by the activity of CB2 receptors or conditions which are mediated by PDE4.
摘要翻译: 一种或多种CB2调节剂与一种或多种PDE4抑制剂的组合,以及治疗由CB2受体的活性或由PDE4介导的病症介导的病症的方法。
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