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1.发明申请Method Of Treating Attention Deficit Disorders With D-Threo Methylphenidate 审中-公开用D-Threo哌甲酯治疗注意力缺陷障碍的方法公开(公告)号：US20110201645A1
公开(公告)日：2011-08-18
申请号：US13093917
申请日：2011-04-26
IPC分类号： A61K31/4458 , A61P25/00
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
摘要翻译： 治疗注意力缺陷障碍，注意力缺陷多动障碍，艾滋病痴呆综合征和艾滋病毒/艾滋病认知衰退的方法，同时通过施用二硫代哌甲酯或药学上可接受的方式尽量减少药物过敏反应，毒性，副作用，欣欣乐效和药物滥用潜力 的盐。
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2.发明申请Methods For Treatment Of Cognitive And Menopausal Disorders With D-Threo Methylphenidate 审中-公开用D-Threo哌甲酯治疗认知障碍和绝经期疾病的方法公开(公告)号：US20100093797A1
公开(公告)日：2010-04-15
申请号：US12640734
申请日：2009-12-17
申请人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
发明人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
IPC分类号： A61K31/445 , A61P15/00 , A61P35/04
CPC分类号： C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。
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公开(公告)号：US5908850A
公开(公告)日：1999-06-01
申请号：US827230
申请日：1997-04-02
IPC分类号： A61K31/4458 , A61K31/445
CPC分类号： A61K31/4458
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
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4.发明申请METHODS FOR TREATMENT OF COGNITIVE AND MENOPAUSAL DISORDERS WITH D-THREO METHYLPHENIDATE 审中-公开用甲基苯甲酸D-THREO治疗认知障碍和男性疾病的方法公开(公告)号：US20130053414A1
公开(公告)日：2013-02-28
申请号：US13661472
申请日：2012-10-26
申请人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
发明人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
IPC分类号： A61K31/4458 , A61P25/00 , A61P25/24 , A61P3/00
CPC分类号： C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。
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公开(公告)号：US5922736A
公开(公告)日：1999-07-13
申请号：US937684
申请日：1997-09-29
IPC分类号： A61K9/16 , A61K9/28 , A61K9/50 , A61K9/54 , A61K31/4458 , A61P25/28 , C07D211/34 , C12P17/12 , C12P41/00 , A61K31/445
CPC分类号： A61K31/445 , A61K31/4458 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
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公开(公告)号：US06255325B1
公开(公告)日：2001-07-03
申请号：US09337310
申请日：1999-06-21
IPC分类号： A61K31445
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
摘要翻译： 提供了
D - 特异哌甲酯的慢性推注。 D - 苏氨酸异构体的给药消除了与 DL 外消旋体相关的不良副作用，并提供更好的效果。 本发明的组合物和方法可用于治疗神经系统疾病，包括注意力缺陷障碍，注意缺陷多动障碍以及与系统性疾病如获得性免疫缺陷综合征相关的认知衰退。 -
公开(公告)号：US20090088455A1
公开(公告)日：2009-04-02
申请号：US12331127
申请日：2008-12-09
IPC分类号： A61K31/4458 , A61P25/00
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
摘要翻译： 提供了D-三苯哌甲酯的慢性推注。 D-苏糖异构体的给药消除了与DL外消旋相关的不利副作用，并提供了改善的效果。 本发明的组合物和方法可用于治疗神经系统疾病，包括注意力缺陷障碍，注意缺陷多动障碍以及与系统性疾病如获得性免疫缺陷综合征相关的认知衰退。
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公开(公告)号：US06355656B1
公开(公告)日：2002-03-12
申请号：US09318151
申请日：1999-05-25
IPC分类号： A61K31445
CPC分类号： A61K45/06 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： Phenidate drug formulations are provided having reduced potential for drug abuse. Dosage forms for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS are provided which minimize drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential. Such dosage forms comprise D-threo stereoisomer of a phenidate in the substantial absence of all other stereoisomers.
摘要翻译： 提供了具有降低药物滥用潜力的苯甲酸药物制剂。 提供用于治疗注意力缺陷障碍，注意力缺陷多动障碍，艾滋病痴呆综合征和艾滋病毒/艾滋病认知衰退的剂量形式，其最小化药物过敏，毒性，副作用，欣快效应和药物滥用潜力。 这样的剂型在实质上不存在所有其它立体异构体的情况下包括苯甲酸酯的
D - 立体异构体。 -
9.发明申请METHOD OF TREATING ATTENTION DEFICIT DISORDERS WITH D-THREO METHYLPHENIDATE 审中-公开用D-甲基苯甲酸酯治疗缺陷性疾病的方法公开(公告)号：US20130109719A1
公开(公告)日：2013-05-02
申请号：US13721224
申请日：2012-12-20
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
摘要翻译： 治疗注意力缺陷障碍，注意力缺陷多动障碍，艾滋病痴呆综合征和艾滋病毒/艾滋病认知衰退的方法，同时通过施用二硫代哌甲酯或药学上可接受的方式尽量减少药物过敏反应，毒性，副作用，欣欣乐效和药物滥用潜力 的盐。
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10.发明申请Method Of Treating Attention Deficit Disorders With D-Threo Methylphenidate 审中-公开用D-Threo哌甲酯治疗注意力缺陷障碍的方法公开(公告)号：US20100035928A1
公开(公告)日：2010-02-11
申请号：US12580800
申请日：2009-10-16
IPC分类号： A61K31/445 , A61P25/00
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
摘要翻译： 治疗注意力缺陷障碍，注意力缺陷多动障碍，艾滋病痴呆综合征和艾滋病毒/艾滋病认知衰退的方法，同时通过施用二硫代哌甲酯或药学上可接受的方式尽量减少药物过敏反应，毒性，副作用，欣欣乐效和药物滥用潜力 的盐。
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