专利检索 ap:("Andrew Simon Bell" OR "Alan Daniel Brown" OR "Marcel John De Groot" OR "Russell Andrew Lewthwaite" OR "Ian Roger Marsh" OR "David Simon Millan" OR "Manuel Perez Pacheco" OR "David James Rawson" OR "Nunzio Sciammetta" OR "Robert Ian Storer" OR "Nigel Alan Swain" OR "Steven Matthieu Gaulier") AND inv:"Ian Roger Marsh" 第 1 页

1.

发明申请
Chemical Compounds 有权
标题翻译：化学化合物

公开(公告)号：US20120010183A1

公开(公告)日：2012-01-12

申请号：US13179587

申请日：2011-07-11

申请人： Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier

发明人： Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier

IPC分类号： A61K31/44 , C07D401/04 , C07D215/20 , C07D405/12 , C07D231/56 , A61P29/00 , A61K31/506 , A61K31/47 , A61K31/4427 , A61K31/416 , A61K31/4545 , A61K31/4439 , C07D213/69 , C07D401/12

CPC分类号： C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04

摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

摘要翻译： 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中Het1，X，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

2.

发明授权
Sulfonamide derivatives as Nav 1.7 inhibitors 有权
标题翻译：磺酰胺衍生物作为Nav 1.7抑制剂

公开(公告)号：US08592629B2

公开(公告)日：2013-11-26

申请号：US13179587

申请日：2011-07-11

申请人： Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier

发明人： Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier

IPC分类号： C07C303/00 , A61K31/18

CPC分类号： C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04

摘要： This invention relates to sulfonamide derivative of formula (I), to their use in medicine, to compositions containing them, to processes for their preparation, and to intermediates used in such processes. These compounds are inhibitors of Nav1.7.

摘要翻译： 本发明涉及式（I）的磺酰胺衍生物，其在药物中的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。这些化合物是Nav1.7的抑制剂。

3.

发明申请
Chemical Compounds 失效
标题翻译：化学化合物

公开(公告)号：US20120010207A1

公开(公告)日：2012-01-12

申请号：US13179585

申请日：2011-07-11

申请人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot

发明人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot

IPC分类号： A61K31/18 , C07D231/12 , C07D233/64 , A61P29/00 , A61K31/415 , A61K31/4164 , A61K31/50 , A61K31/277 , C07C311/51 , C07D237/08

CPC分类号： C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08

摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

摘要翻译： 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中Ar1，X，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

4.

发明授权
Chemical compounds 失效
标题翻译：化合物

公开(公告)号：US08685977B2

公开(公告)日：2014-04-01

申请号：US13179585

申请日：2011-07-11

申请人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot

发明人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot

IPC分类号： A01N43/58 , A61K31/50 , A01N43/40 , A61K31/435 , A01N43/56 , A61K31/415 , A01N43/36 , A61K31/40

CPC分类号： C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08

摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

摘要翻译： 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中Ar1，X，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

5.

发明申请
Pyrazolo[4,3-D]Pyrimidines 失效
标题翻译：吡唑并[4,3-D]嘧啶

公开(公告)号：US20080293697A1

公开(公告)日：2008-11-27

申请号：US10599702

申请日：2005-03-30

申请人： Andrew Simon Bell , David Graham Brown , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Dafydd Rhys Owen , Michael John Palmer , Carol Ann Winslow , Hwang Fun Lu , Thomas Edward Rogers

发明人： Andrew Simon Bell , David Graham Brown , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Dafydd Rhys Owen , Michael John Palmer , Carol Ann Winslow , Hwang Fun Lu , Thomas Edward Rogers

IPC分类号： C07D487/04 , A61K31/519 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P9/00

CPC分类号： C07D487/04

摘要： This invention relates to compounds of formula (I).

摘要翻译： 本发明涉及式（I）化合物。

6.

发明申请
Novel Pharmaceuticals 有权
标题翻译：新药

公开(公告)号：US20090247539A1

公开(公告)日：2009-10-01

申请号：US12481939

申请日：2009-06-10

申请人： Andrew Simon Bell , David Graham Brown , Kevin Dack , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Michael John Palmer , Carol Ann Winslow

发明人： Andrew Simon Bell , David Graham Brown , Kevin Dack , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Michael John Palmer , Carol Ann Winslow

IPC分类号： A61K31/519 , C07D487/04 , A61P9/12

CPC分类号： C07D487/04

摘要： This invention relates to compounds of formula (I)

摘要翻译： 本发明涉及式（I）化合物，

7.

发明授权
Substituted pyrazolo[4,3-d]pyrimidines and their use as PDE-5 inhibitors 有权
标题翻译：取代的吡唑并[4,3-d]嘧啶并将其用作PDE-5抑制剂

公开(公告)号：US07262192B2

公开(公告)日：2007-08-28

申请号：US10834484

申请日：2004-04-29

申请人： Andrew Simon Bell , David Graham Brown , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Michael John Palmer , Carol Ann Winslow

发明人： Andrew Simon Bell , David Graham Brown , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Michael John Palmer , Carol Ann Winslow

IPC分类号： A61K31/5355 , A61K31/497 , A61K31/519 , C07D487/04 , C07D413/04 , A61P9/12

CPC分类号： C07D487/04

摘要： The present invention comprises a class of 5,7-diaminopyrazolo[4,3-d]pyrimidine compounds. These compounds are useful as phosphodiesterase type 5 inhibitors. The present invention further comprises compositions containing the compounds use of the compounds and compositions to treat hypertension and other conditions, processes for the preparation of the compounds, and intermediates used in the preparation of the compounds.

摘要翻译： 本发明包括一类5,7-二氨基吡唑并[4,3-d]嘧啶化合物。这些化合物可用作5型磷酸二酯酶抑制剂。本发明还包含含有化合物和组合物用于治疗高血压和其他病症的化合物的组合物，用于制备化合物的方法和用于制备化合物的中间体。