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1.发明授权Composition containing immature mammalian dendritic cells for enhancing tolerogenicity to foreign graft 失效含有不成熟哺乳动物树突状细胞以增强对外来移植物的耐受性的组合物公开(公告)号：US06224859B1
公开(公告)日：2001-05-01
申请号：US09064829
申请日：1998-04-23
IPC分类号： A01N6300
CPC分类号： A61K39/001 , A61K38/00 , A61K2035/122 , C12N5/064 , C12N2501/22
摘要： A novel transplantation method for enhancing tolerogenicity in a host mammal to a transplant graft specimen from a donor mammal is disclosed. According to this method, immature mammalian dendritic cells propagated in the presence of a cytokine are administered to the host mammal in advance of transplantation. Tolerogenicity is enhanced in the host mammal when the immature mammalian dendritic cells concentrate in T-dependent regions of secondary lymphoid tissue of the host mammal, where the expression of major histocompatibility complex class II antigen by the immature mammalian dendritic cells is upregulated. Also disclosed is a novel method of effecting the maturation of immature dendritic cells in the presence of a cytokine and an extracellular matrix protein. These mature mammalian dendritic cells, which upregulate the expression of major histocompatibility complex class II antigen, can then be used to enhance the immune response of a host mammal.
摘要翻译： 公开了一种用于增强宿主哺乳动物对来自供体哺乳动物的移植移植物标本的耐受性的新型移植方法。 根据该方法，在移植前向宿主哺乳动物施用在细胞因子存在下繁殖的未成熟哺乳动物树突状细胞。 当未成熟的哺乳动物树突状细胞集中在宿主哺乳动物的次级淋巴组织的T依赖区域中时，宿主哺乳动物的耐受性增强，其中未成熟哺乳动物树突状细胞的主要组织相容性复合物II类抗原的表达被上调。 还公开了一种在细胞因子和细胞外基质蛋白的存在下实现未成熟树突状细胞的成熟的新方法。 这些成熟的哺乳动物树突细胞，其上调主要组织相容性复合物II类抗原的表达，然后可以用于增强宿主哺乳动物的免疫应答。
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公开(公告)号：US5871728A
公开(公告)日：1999-02-16
申请号：US414461
申请日：1995-03-31
CPC分类号： A61K39/001 , C12N5/064 , A61K2035/122 , A61K38/00 , C12N2501/22
摘要： A novel transplantation method for enhancing tolerogenicity in a host mammal to a transplant graft specimen from a donor mammal is disclosed. According to this method, immature mammalian dendritic cells propagated in the presence of a cytokine are administered to the host mammal in advance of transplantation. Tolerogenicity is enhanced in the host mammal when the immature mammalian dendritic cells concentrate in T-dependent regions of secondary lymphoid tissue of the host mammal, where the expression of major histocompatibility complex class II antigen by the immature mammalian dendritic cells is upregulated. Also disclosed is a novel method of effecting the maturation of immature dendritic cells in the presence of a cytokine and an extracellular matrix protein. These mature mammalian dendritic cells, which upregulate the expression of major histocompatibility complex class II antigen, can then be used to enhance the immune response of a host mammal.
摘要翻译： 公开了一种用于增强宿主哺乳动物对来自供体哺乳动物的移植移植物标本的耐受性的新型移植方法。 根据该方法，在移植前向宿主哺乳动物施用在细胞因子存在下繁殖的未成熟哺乳动物树突状细胞。 当未成熟的哺乳动物树突状细胞集中在宿主哺乳动物的次级淋巴组织的T依赖区域中时，宿主哺乳动物的耐受性增强，其中未成熟哺乳动物树突状细胞的主要组织相容性复合物II类抗原的表达被上调。 还公开了一种在细胞因子和细胞外基质蛋白的存在下实现未成熟树突状细胞的成熟的新方法。 这些成熟的哺乳动物树突细胞，其上调主要组织相容性复合物II类抗原的表达，然后可以用于增强宿主哺乳动物的免疫应答。
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