公开(公告)号：US20250000804A1

公开(公告)日：2025-01-02

申请号：US18668709

申请日：2024-05-20

Applicant: Anji Pharmaceuticals Inc.

Inventor： Alain D. Baron ,  Mark S. Fineman ,  Terri Kim ,  Stephen Kwaku Dordunoo

IPC: A61K9/28 ,  A61K31/155

Abstract: Compositions and methods for improving the pharmacokinetics and reducing the risk of adverse events resulting from biguanide compound administration are provided, comprising administering delayed release formulations of such compounds having a lag phase release.

公开(公告)号：US11974971B2

公开(公告)日：2024-05-07

申请号：US16273079

申请日：2019-02-11

Applicant: Anji Pharmaceuticals Inc.

Inventor： Alain D. Baron ,  Mark S. Fineman ,  Nigel R. A. Beeley

IPC: A61K31/155 ,  A61K9/00 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48 ,  A61K31/19 ,  A61K31/198 ,  A61K31/7016 ,  A61K31/704 ,  A61K45/06

CPC classification number: A61K31/155 ,  A61K9/0053 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2846 ,  A61K9/4808 ,  A61K31/19 ,  A61K31/198 ,  A61K31/7016 ,  A61K31/704 ,  A61K45/06

Abstract: Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.

公开(公告)号：US11759441B2

公开(公告)日：2023-09-19

申请号：US17375807

申请日：2021-07-14

Applicant: Anji Pharmaceuticals Inc.

Inventor： Alain D. Baron ,  Mark S. Fineman ,  Nigel R. A. Beeley

IPC: A61K31/155 ,  A61P3/10 ,  A61K9/20 ,  A61K9/48 ,  A61K9/28 ,  A61K45/06 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/53 ,  A61K31/4196 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/55 ,  A61P3/08 ,  A61K31/137 ,  A61K31/35 ,  A61K31/485

CPC classification number: A61K31/155 ,  A61K9/2086 ,  A61K9/2806 ,  A61K9/4808 ,  A61K31/137 ,  A61K31/341 ,  A61K31/35 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/485 ,  A61K31/53 ,  A61K31/55 ,  A61K45/06 ,  A61P3/08 ,  A61P3/10

Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.