公开(公告)号：US20080287412A1

公开(公告)日：2008-11-20

申请号：US12180979

申请日：2008-07-28

申请人： Ann R. Comfort ,  William L. Daley ,  Santo J. Fleres ,  Alan E. Royce ,  Randy L. Webb ,  William S. Wei

发明人： Ann R. Comfort ,  William L. Daley ,  Santo J. Fleres ,  Alan E. Royce ,  Randy L. Webb ,  William S. Wei

IPC分类号： A61K31/55 ,  B05D3/02 ,  A61P9/12

CPC分类号： A61F2/02 ,  A61F2250/0067

摘要： The present invention especially relates to the use of a combination comprising(1) an ACEI selected from the group consisting of benazepril, benazeprilat, and pharmaceutically acceptable salts thereof, and (2) amlodipine or pharmaceutically acceptable salt thereof, for the manufacture a medicament for the treatment or prevention or delay of progression of a condition selected from the group consisting of hypertension, congestive heart failure, angina, myocardial infarction, artherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, blood pressure-related cerebrovasular disease, stroke, pulmonary disease or pulmonary hypertension and headache; wherein (i) the amount of amlodipine or a pharmaceutically acceptable salt thereof corresponds to 6 about mg to 40 about mg of the free base and (ii) the amount of the ACE inhibitor or a pharmaceutically thereof corresponds to 20 about mg to 160 about mg of benazepril hydrochloride.

摘要翻译： 本发明特别涉及组合的用途，其包含（1）选自苯那普利，贝那普利拉和其药学上可接受的盐的ACEI，和（2）氨氯地平或其药学上可接受的盐，用于制备用于 选自高血压，充血性心力衰竭，心绞痛，心肌梗塞，动脉粥样硬化，糖尿病肾病，糖尿病心肌病，肾功能不全，外周血管疾病，左心室肥大，认知功能障碍的病症的治疗或预防或延迟进展 ，血压相关性脑血管病，中风，肺部疾病或肺动脉高压和头痛; 其中（i）氨氯地平或其药学上可接受的盐的量对应于约约40mg至约40mg的游离碱，和（ii）ACE抑制剂或其药学上的量相当于约20mg至约160mg 的贝那普利盐酸盐。