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    THERAPEUTIC COMBINATION OF AMLODIPINE AND BENAZEPRIL/BENAZEPRILAT
    1.
    发明申请
    THERAPEUTIC COMBINATION OF AMLODIPINE AND BENAZEPRIL/BENAZEPRILAT 审中-公开
    阿维菌素和贝那普利/贝那韦特的治疗组合

    公开(公告)号：US20080287412A1

    公开(公告)日：2008-11-20

    申请号：US12180979

    申请日：2008-07-28

    申请人： Ann R. Comfort ,  William L. Daley ,  Santo J. Fleres ,  Alan E. Royce ,  Randy L. Webb ,  William S. Wei

    发明人： Ann R. Comfort ,  William L. Daley ,  Santo J. Fleres ,  Alan E. Royce ,  Randy L. Webb ,  William S. Wei

    IPC分类号： A61K31/55 ,  B05D3/02 ,  A61P9/12

    CPC分类号： A61F2/02 ,  A61F2250/0067

    摘要： The present invention especially relates to the use of a combination comprising(1) an ACEI selected from the group consisting of benazepril, benazeprilat, and pharmaceutically acceptable salts thereof, and (2) amlodipine or pharmaceutically acceptable salt thereof, for the manufacture a medicament for the treatment or prevention or delay of progression of a condition selected from the group consisting of hypertension, congestive heart failure, angina, myocardial infarction, artherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, blood pressure-related cerebrovasular disease, stroke, pulmonary disease or pulmonary hypertension and headache; wherein (i) the amount of amlodipine or a pharmaceutically acceptable salt thereof corresponds to 6 about mg to 40 about mg of the free base and (ii) the amount of the ACE inhibitor or a pharmaceutically thereof corresponds to 20 about mg to 160 about mg of benazepril hydrochloride.

    摘要翻译： 本发明特别涉及组合的用途，其包含（1）选自苯那普利，贝那普利拉和其药学上可接受的盐的ACEI，和（2）氨氯地平或其药学上可接受的盐，用于制备用于 选自高血压，充血性心力衰竭，心绞痛，心肌梗塞，动脉粥样硬化，糖尿病肾病，糖尿病心肌病，肾功能不全，外周血管疾病，左心室肥大，认知功能障碍的病症的治疗或预防或延迟进展 ，血压相关性脑血管病，中风，肺部疾病或肺动脉高压和头痛; 其中（i）氨氯地平或其药学上可接受的盐的量对应于约约40mg至约40mg的游离碱，和（ii）ACE抑制剂或其药学上的量相当于约20mg至约160mg 的贝那普利盐酸盐。

    Melt granulated compositions for preparing sustained release dosage forms
    2.
    发明授权
    Melt granulated compositions for preparing sustained release dosage forms 失效
    用于制备缓释剂型的熔融颗粒组合物

    公开(公告)号：US5403593A

    公开(公告)日：1995-04-04

    申请号：US860920

    申请日：1992-03-31

    申请人： Alan E. Royce

    发明人： Alan E. Royce

    IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K9/14

    CPC分类号： A61K9/1652 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/2095

    摘要： Therapeutically active sustained release dosage forms are described which are prepared from compositions which comprise (A) a hydrophilic cellulose ether polymer or mixtures thereof as a binder matrix material, (B) a granulating medium selected from the group consisting of a lipid component, polyethylene glycol polymers, and mixtures thereof, said granulating medium having a melting range higher than about 30.degree. C., and (C) a therapeutically active medicament, said components being in melt association. The compositions are prepared by a melt granulation process.

    摘要翻译： 描述了治疗活性持续释放剂型，其由包含（A）亲水性纤维素醚聚合物或其混合物作为粘合剂基质材料的组合物制备，（B）选自由脂质组分，聚乙二醇 聚合物及其混合物，所述造粒介质具有高于约30℃的熔融温度，和（C）治疗活性药物，所述组分是熔融缔合的。 通过熔融制粒方法制备组合物。

    Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms
    8.
    发明授权
    Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms 失效
    用于制备治疗剂型的直接可压缩聚环氧乙烷载体

    公开(公告)号：US5273758A

    公开(公告)日：1993-12-28

    申请号：US868073

    申请日：1992-04-13

    申请人： Alan E. Royce

    发明人： Alan E. Royce

    IPC分类号： A61K9/20

    CPC分类号： A61K9/2031

    摘要： Polyethylene oxide polymer is employed as a directly compressible binder matrix for therapeutically active dosage forms. Advantageously, the polyethylene oxide has an adjustable rate control effect on the release of medicament from the dosage form, enabling in particular the preparation of sustained release dosage forms.

    摘要翻译： 聚环氧乙烷聚合物用作治疗活性剂型的直接可压缩粘合剂基质。 有利地，聚环氧乙烷对于剂型释放药物具有可调整的速率控制作用，特别是能够制备缓释剂型。

    Pulsatile drug delivery system
    9.
    发明授权
    Pulsatile drug delivery system 失效
    脉动药物输送系统

    公开(公告)号：US4723958A

    公开(公告)日：1988-02-09

    申请号：US866415

    申请日：1986-05-23

    申请人： David G. Pope ,  Alan E. Royce

    发明人： David G. Pope ,  Alan E. Royce

    IPC分类号： A01N25/00 ,  A61K9/00 ,  A61K9/22 ,  A61M31/00

    CPC分类号： A61K9/0004 ,  A61M31/002

    摘要： There is provided a novel drug delivery system which provides for intermittent drug delivery with readily adjustable intervals between drug delivery pulses. This is accomplished by providing a multilayer device in which layers of active drug are readily expandable or erodable when contacted with the environment in which the drug is to be administered. The drug layer is alternated with an inert layer and a multiplicity of such layers are contained within a tube impervious to such environment but provided with an opening into such environment. The multiplicity of such layers is driven along the length of such tube towards the opening. The interval between pulses is determined by the rate the layers are driven along the tube and the sizes of the layers. The duration of the pulse is determined by the rate of expansion or dispersion of the active layer into the environment, wherein the rate of expansion or dispersion is greater than the rate the layers are driven along the tube.

    摘要翻译： 提供了一种新颖的药物递送系统，其提供间歇药物递送，并且药物递送脉冲之间具有容易调节的间隔。 这通过提供一种多层装置来实现，其中活性药物层当与待施用药物的环境接触时易于扩张或可侵蚀。 药物层与惰性层交替，并且多个这样的层被包含在不能透过这种环境但在这种环境中具有开口的管中。 这种层的多重性沿着这种管的长度朝着开口被驱动。 脉冲之间的间隔由层沿着管驱动的速率和层的尺寸决定。 脉冲的持续时间由活性层进入环境的膨胀或分散速率确定，其中膨胀或分散速率大于沿着管驱动层的速率。

    Emulsion-based gel and process for preparing same
    10.
    发明授权
    Emulsion-based gel and process for preparing same 失效
    基于乳液的凝胶及其制备方法

    公开(公告)号：US4690775A

    公开(公告)日：1987-09-01

    申请号：US726923

    申请日：1985-04-25

    申请人： Hans Schott ,  Alan E. Royce

    发明人： Hans Schott ,  Alan E. Royce

    IPC分类号： B01J13/00

    CPC分类号： B01J13/0065

    摘要： Stable, isotropic gels which can be readily redispersed/reconstiuted into fluid emulsions, as such providing useful carriers for a wide variety of substances having little or no solubility in water, e.g., some types of drugs, are prepared by centrifuging an emulsion comprising a substantially oleophilic, hydrophobic liquid component constituting the dispersed phase in a substantially aqueous liquid component containing an emulsifying amount of emulsifying amount of emulsifying agent which is soluble therein at its level of concentration but which is substantially insoluble in the oleophilic, hydrophobic component, the emulsion being devoid of gelling agent, to separate the emulsion into a gel phase containing substantially all of the oleophilic, hydrophobic component of the emulsion and a clear aqueous phase.

    摘要翻译： 稳定的各向同性凝胶可以容易地再分散/重新分散成流体乳液，因此为多种在水中具有很少或不溶性的物质提供有用的载体，例如某些类型的药物，通过将包含基本上 构成分散相的亲油疏水性液体组分在含有乳化剂量的乳化剂的基本上含水的液体组分中，乳化剂的浓度水平可溶于其中，但基本上不溶于亲油疏水组分，乳液不含 的胶凝剂，以将乳液分离成基本上含有乳液的亲油，疏水组分和透明水相的凝胶相。