公开(公告)号：US08143029B2

公开(公告)日：2012-03-27

申请号：US12086712

申请日：2006-12-21

申请人： Annamari Ranki ,  Sonja Hahtola ,  Leena Karenko ,  Soile Tuomela ,  Riitta Lahesmaa ,  Kai J. E Krohn

发明人： Annamari Ranki ,  Sonja Hahtola ,  Leena Karenko ,  Soile Tuomela ,  Riitta Lahesmaa ,  Kai J. E Krohn

IPC分类号： C12P19/34 ,  C12Q1/68 ,  C12M1/34

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The present invention relates to the fields of genetics and oncology and provides methods for detecting cutaneous T-cell lymphomas (CTCL) or susceptibility to CTCL. Specifically, the present invention relates to a novel method for the diagnosis and follow-up of CTCL or CTCL subtype, the method comprising determination of expression of one or more genes, gene fragments or gene products. The present invention further relates to a novel method of detecting the response to CTCL therapy, the method comprising determining expression of one or more genes or gene fragments or gene products in a biological sample. The present invention further relates to a novel method of developing or improving CTCL therapy or developing anti-CTCL medicament, the method comprising screening agents affecting one or several of the genes or gene products. The present invention further relates to a novel method of treating CTCL patients, the method comprising affecting one or several of the genes or gene products. The present invention further relates to a novel test kit, the kit comprising the necessary means for detecting one or more genes, gene fragments or gene products. The present invention also relates to a use of one or more genes, gene fragments or gene products for determination, diagnosis or follow-up of CTCL or CTCL subtype and for detection of the response to CTCL therapy. The present invention also relates to a use of one or more target molecules for CTCL therapy or for the preparation of a medicament for treating CTCL.

摘要翻译： 本发明涉及遗传学和肿瘤学领域，并提供了检测皮肤T细胞淋巴瘤（CTCL）或对CTCL敏感性的方法。 具体地说，本发明涉及一种诊断和追踪CTCL或CTCL亚型的新方法，该方法包括测定一种或多种基因，基因片段或基因产物的表达。 本发明还涉及检测对CTCL治疗的反应的新方法，所述方法包括测定生物样品中一种或多种基因或基因片段或基因产物的表达。 本发明还涉及一种开发或改进CTCL治疗或开发抗CTCL药物的新方法，该方法包括影响一种或几种基因或基因产物的筛选剂。 本发明还涉及一种治疗CTCL患者的新方法，该方法包括影响一种或几种基因或基因产物。 本发明还涉及一种新的测试试剂盒，该试剂盒包含检测一种或多种基因，基因片段或基因产物的必要手段。 本发明还涉及一种或多种基因，基因片段或基因产物用于测定，诊断或追踪CTCL或CTCL亚型以及检测对CTCL治疗的应答​​的用途。 本发明还涉及一种或多种靶分子用于CTCL治疗或制备用于治疗CTCL的药物的用途。