公开(公告)号：US09732324B2

公开(公告)日：2017-08-15

申请号：US13125756

申请日：2009-10-23

申请人： Anne Moscona ,  Matteo Porotto ,  David Alexander LaVan ,  Feng Yi

发明人： Anne Moscona ,  Matteo Porotto ,  David Alexander LaVan ,  Feng Yi

IPC分类号： C12Q1/70 ,  A61K39/155 ,  C12N7/00

CPC分类号： C12N7/00 ,  C12N2760/18261

摘要： The invention provides a method of reducing viral infectivity in a sample comprising contacting the sample with a earner matrix wherein lipids are attached to the carrier matrix, and wherein at least one virus-specific agent is attached to the lipids The virus-specific agent is capable of binding to at least one viral component The virus specific agent may be a receptor The earner matrix may be a silica particle, which may be coated with a lipid bilayer The invention further provides a method of inactivating a virus comprising contacting the virus with a earner matrix wherein lipids are attached to the earner matrix, and wherein at least one receptor is attached to the lipids, binding the receptor to at least one viral receptor-binding protein, and activating at least one viral fusion protein, wherein activation inactivates the virus, and releases the virus from the earner matrix.

公开(公告)号：US20120039978A1

公开(公告)日：2012-02-16

申请号：US13125756

申请日：2009-10-23

申请人： Anne Moscona ,  Matteo Porotto ,  David LaVan ,  Feng Yi

发明人： Anne Moscona ,  Matteo Porotto ,  David LaVan ,  Feng Yi

IPC分类号： A61K9/14 ,  A01N25/26 ,  A61K38/04 ,  C12N7/06 ,  A01P1/00 ,  A61P31/12 ,  A61P31/14 ,  A01N37/18 ,  A01N25/08

CPC分类号： C12N7/00 ,  C12N2760/18261

摘要： The invention provides a method of reducing viral infectivity in a sample compnsing contacting the sample with a earner matrix wherein lipids are attached to the carrier matrix, and wherein at least one virus-specific agent is attached to the lipids The virus-specific agent is capable of binding to at least one viral component The virus specific agent may be a receptor The earner matrix may be a silica particle, which may be coated with a lipid bilayer The invention further provides a method of inactivating a virus comprising contacting the virus with a earner matrix wherein lipids are attached to the earner matrix, and wherein at least one receptor is attached to the lipids, binding the receptor to at least one viral receptor-binding protein, and activating at least one viral fusion protein, wherein activation inactivates the virus, and releases the virus from the earner matrix

摘要翻译： 本发明提供了一种降低样品中病毒感染性的方法，该方法使样品与载体基质接触，其中脂质连接到载体基质上，并且其中至少一种病毒特异性试剂连接至脂质。病毒特异性试剂能够 与至少一种病毒组分结合的病毒特异性试剂可以是受体。载体基质可以是可以用脂质双层包被的二氧化硅颗粒。本发明还提供灭活病毒的方法，包括使病毒与载体接触 基质，其中脂质连接到载体基质上，并且其中至少一种受体连接到脂质上，将受体结合至至少一种病毒受体结合蛋白，以及激活至少一种病毒融合蛋白，其中活化使病毒失活， 并从载体矩阵中释放病毒