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公开(公告)号：US20060275296A1
公开(公告)日：2006-12-07
申请号：US11430066
申请日：2006-05-08
IPC分类号： A61K39/395 , C12N5/06 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885 , Y10S514/886
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明进一步提供产生单克隆抗体的杂交瘤。
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公开(公告)号：US20090220417A1
公开(公告)日：2009-09-03
申请号：US12420747
申请日：2009-04-08
IPC分类号： A61K39/395 , A61K51/00 , A61K49/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885 , Y10S514/886
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明进一步提供产生单克隆抗体的杂交瘤。
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公开(公告)号：US08568723B2
公开(公告)日：2013-10-29
申请号：US13185130
申请日：2011-07-18
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885 , Y10S514/886
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的迟发型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明进一步提供产生单克隆抗体的杂交瘤。
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公开(公告)号：US07531637B2
公开(公告)日：2009-05-12
申请号：US11430066
申请日：2006-05-08
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885 , Y10S514/886
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明进一步提供产生单克隆抗体的杂交瘤。
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公开(公告)号：US20110293514A1
公开(公告)日：2011-12-01
申请号：US13185130
申请日：2011-07-18
IPC分类号： A61K51/10 , A61P17/04 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885 , Y10S514/886
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的迟发型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明进一步提供产生单克隆抗体的杂交瘤。
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公开(公告)号：US08017122B2
公开(公告)日：2011-09-13
申请号：US12420747
申请日：2009-04-08
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885 , Y10S514/886
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明进一步提供产生单克隆抗体的杂交瘤。
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公开(公告)号：US20100092465A1
公开(公告)日：2010-04-15
申请号：US12438903
申请日：2007-08-27
申请人： Nancy Hosken , Kelly Byrnes-Blake , Ty Brender , Monica Huber , Margaret Moore , Shirley Rene , Mark Rixon , Sara Underwood , Kimberly Waggie
发明人： Nancy Hosken , Kelly Byrnes-Blake , Ty Brender , Monica Huber , Margaret Moore , Shirley Rene , Mark Rixon , Sara Underwood , Kimberly Waggie
IPC分类号： A61K39/395 , A61P37/06
CPC分类号： C07K16/2866 , A61K38/1793 , A61K2039/505 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Methods for treating graft-versus-host disease, methods for reducing symptoms of graft-versus-host disease, and methods of reducing the severity of graft-versus-host disease in a patient are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.
摘要翻译： 公开了用于治疗移植物抗宿主病的方法，减少移植物抗宿主病的症状的方法以及降低患者中移植物抗宿主病的严重性的方法。 所述方法包括向患者施用治疗有效量的IL-27拮抗剂与药学上可接受的载体的组合。 IL-27拮抗剂包括可溶性IL-27RA蛋白和包含抗体的抗原结合位点的拮抗剂。
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8.发明申请VARIABLE REGION SEQUENCES OF IL-31 MONOCLONAL ANTIBODIES AND METHODS OF USE 有权IL-31单克隆抗体的可变区域序列及其使用方法公开(公告)号：US20090252732A1
公开(公告)日：2009-10-08
申请号：US11850006
申请日：2007-09-04
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention provides the hybridomas that generate the monoclonal antibodies and the amino acid sequences of the variable regions of the monoclonal antibodies and chimeric antibodies comprising the amino acid sequences of the light and heavy chain variable regions.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明提供产生单克隆抗体的杂交瘤和单克隆抗体的可变区的氨基酸序列和包含轻链和重链可变区的氨基酸序列的嵌合抗体。
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公开(公告)号：US08101183B2
公开(公告)日：2012-01-24
申请号：US11850006
申请日：2007-09-04
申请人： Anthony W. Siadak , Shirley Rene
发明人： Anthony W. Siadak , Shirley Rene
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention provides the hybridomas that generate the monoclonal antibodies and the amino acid sequences of the variable regions of the monoclonal antibodies and chimeric antibodies comprising the amino acid sequences of the light and heavy chain variable regions.
摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明提供产生单克隆抗体的杂交瘤和单克隆抗体的可变区的氨基酸序列和包含轻链和重链可变区的氨基酸序列的嵌合抗体。
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公开(公告)号：US20100008917A1
公开(公告)日：2010-01-14
申请号：US12438909
申请日：2007-08-27
申请人： Nancy Hosken , Kelly Byrnes-Blake , Ty Brender , Monica J. Huber , Margaret D. Moore , Shirley Rene , Mark W. Rixon , Sara Underwood
发明人： Nancy Hosken , Kelly Byrnes-Blake , Ty Brender , Monica J. Huber , Margaret D. Moore , Shirley Rene , Mark W. Rixon , Sara Underwood
IPC分类号： A61K39/395
CPC分类号： A61K9/0019 , A61K38/1793 , A61K2039/505 , C07K16/2866 , C07K2319/30 , A61K2300/00
摘要： Methods of treating aplastic anemia in a patient and of increasing blood cell production in a patient having aplastic anemia are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.
摘要翻译： 公开了治疗再生障碍性贫血患者的再生障碍性贫血的治疗方法和增加血细胞生成的方法。 所述方法包括向患者施用治疗有效量的IL-27拮抗剂与药学上可接受的载体。 IL-27拮抗剂包括可溶性IL-27RA蛋白和包含抗体的抗原结合位点的拮抗剂。
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