专利检索 ap:("Antonella CONVERSO" OR "Abdellatif EL MARROUNI" OR "Ashley FORSTER" OR "Jessica L. FRIE" OR "David N. HUNTER" OR "Cheng WANG" OR "Deping WANG" OR "Merck Sharp & Dohme Corp.") AND inv:"Abdellatif El Marrouni" 第 1 页

1.

发明申请
PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS 有权

公开(公告)号：US20220242847A1

公开(公告)日：2022-08-04

申请号：US17611448

申请日：2020-05-18

申请人： Antonella CONVERSO , Abdellatif EL MARROUNI , Ashley FORSTER , Jessica L. FRIE , David N. HUNTER , Cheng WANG , Deping WANG , Merck Sharp & Dohme Corp.

发明人： Antonella Converso , Abdellatif El Marrouni , Ashley Forster , Jessica L. Frie , David N. Hunter , Cheng Wang , Deping Wang

IPC分类号： C07D401/06 , C07D401/14 , A61K45/06 , A61K31/506 , A61P31/18

摘要： The present disclosure is directed to pyridinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

2.

发明申请
PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS 有权

公开(公告)号：US20220064147A1

公开(公告)日：2022-03-03

申请号：US17413882

申请日：2019-12-13

申请人： Merck Sharp & Dohme Corp.

发明人： Antonella Converso , Abdellatif El Marrouni , Ashley Forster , Jessica L. Frie , David N. Hunter , Scott D. Kuduk , Helen J. Mitchell , Philippe Nantermet , Deyou Sha , William Daniel Shipe , Cheng Wang , Deping Wang

IPC分类号： C07D403/06 , A61K45/06

摘要： The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

3.

发明申请
TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS 有权

公开(公告)号：US20220062284A1

公开(公告)日：2022-03-03

申请号：US17411341

申请日：2021-08-25

申请人： Merck Sharp & Dohme Corp.

发明人： Antonella Converso , Abdellatif El Marrouni , Anthony W. Shaw , David N. Hunter , Ashley Forster , Cheng Wang , Yunlong Zhang

IPC分类号： A61K31/513 , A61K45/06 , C07D403/06 , C07D401/06 , A61P31/18

摘要： The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).