公开(公告)号：US20120220797A1

公开(公告)日：2012-08-30

申请号：US13387573

申请日：2010-07-26

申请人： Antonio Lorente Bonde-Larsen ,  Pablo Martín Pascual ,  Mario Laderas Muñoz ,  Luis Gerardo Gutiérrez Fuentes

发明人： Antonio Lorente Bonde-Larsen ,  Pablo Martín Pascual ,  Mario Laderas Muñoz ,  Luis Gerardo Gutiérrez Fuentes

IPC分类号： C07C67/30 ,  C07C69/353

CPC分类号： C07C229/38 ,  C07C213/08 ,  C07C219/28

摘要： The invention relates to a process for obtaining 3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising a chemoselective reduction of the acid group against the ester group in compounds of general formula (V), wherein R1 is C1-C8 alkyl; and R3 and R4, independently of one another, represent H or C1-C8 alkyl, or together form a ring of 3 to 7 members with the nitrogen to which they are bound. The invention also relates to the compounds of formula (V), as well as their enantiomers, solvates and salts.

摘要翻译： 本发明涉及一种获得通式（I）的3,3-二苯基丙胺，特别是西妥乐定及其对映异构体，溶剂化物和盐的方法，其包括在通式（I）的化合物中化学选择性还原酸基团与酯基 （Ⅴ），其中R1是C1-C8烷基; 并且R 3和R 4彼此独立地表示H或C 1 -C 8烷基，或者一起形成3至7个与其结合的氮的成员的环。 本发明还涉及式（V）化合物及其对映体，溶剂合物和盐。

公开(公告)号：US08722920B2

公开(公告)日：2014-05-13

申请号：US13387573

申请日：2010-07-26

申请人： Antonio Lorente Bonde-Larsen ,  Pablo Martín Pascual ,  Mario Laderas Muñoz ,  Luis Gerardo Gutiérrez Fuentes

发明人： Antonio Lorente Bonde-Larsen ,  Pablo Martín Pascual ,  Mario Laderas Muñoz ,  Luis Gerardo Gutiérrez Fuentes

IPC分类号： C07C229/38 ,  C07C63/04

CPC分类号： C07C229/38 ,  C07C213/08 ,  C07C219/28

摘要： The invention relates to a process for obtaining 3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising a chemoselective reduction of the acid group against the ester group in compounds of general formula (V), wherein R1 is C1-C8 alkyl; and R3 and R4, independently of one another, represent H or C1-C8 alkyl, or together form a ring of 3 to 7 members with the nitrogen to which they are bound. The invention also relates to the compounds of formula (V), as well as their enantiomers, solvates and salts.

摘要翻译： 本发明涉及一种获得通式（I）的3,3-二苯基丙胺，特别是西妥乐定及其对映异构体，溶剂化物和盐的方法，其包括在通式（I）的化合物中化学选择性还原酸基团与酯基 （Ⅴ），其中R1是C1-C8烷基; 并且R 3和R 4彼此独立地表示H或C 1 -C 8烷基，或者一起形成3至7个与其结合的氮的成员的环。 本发明还涉及式（V）化合物及其对映体，溶剂合物和盐。