公开(公告)号：US20130263294A1

公开(公告)日：2013-10-03

申请号：US13824842

申请日：2011-09-19

申请人： Antonio Martinez ,  Laureano Simon ,  Diego Tejedor ,  Marta Artieda ,  Nerea Bartolome ,  Jose Escaich ,  Alfonso Velasco ,  Miriam Selles ,  Carlos Chetrit ,  Daniel Martinez ,  Armand Sanchez ,  Olga Francino ,  Elisenda Sanchez

发明人： Antonio Martinez ,  Laureano Simon ,  Diego Tejedor ,  Marta Artieda ,  Nerea Bartolome ,  Jose Escaich ,  Alfonso Velasco ,  Miriam Selles ,  Carlos Chetrit ,  Daniel Martinez ,  Armand Sanchez ,  Olga Francino ,  Elisenda Sanchez

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

摘要： A method for predicting risk of joint dysplasia, osteoarthritis and/or a condition that is secondary to joint dysplasia in a mammalian subject of the order Carnivora, the method comprising: (a) determining the genotype of said subject in respect of one or more genetic polymorphisms and/or alterations, such as polymorphisms in the CHST3 gene; and (b) providing a prediction of said risk based on said genotype. Products for use in such a method and related methods of determining propensity of a subject to respond to therapy and of selective breeding, are also disclosed.

摘要翻译： 一种用于预测关节发育不良，骨关节炎和/或继发于哺乳动物食肉动物主题的关节发育不良的病症的方法，所述方法包括：（a）确定所述受试者关于一种或多种遗传物质的基因型 多态性和/或改变，如CHST3基因的多态性; 和（b）基于所述基因型提供所述风险的预测。 还公开了用于确定受试者对治疗和选择性育种的倾向的这种方法和相关方法的产品。