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1.发明申请MODIFIED GP140 ENVELOPE POLYPEPTIDES OF HIV-1 ISOLATES, COMPOSITIONS, STABILIZED TRIMERIC COMPLEXES, AND USES THEREOF 审中-公开HIV-1分离株，组合物，稳定化的TRIMERIC复合物的改性GP140环糊精及其用途公开(公告)号：US20110250220A1
公开(公告)日：2011-10-13
申请号：US13100941
申请日：2011-05-04
申请人： Antu K. Dey , John P. Moore , William C. Olson , Sai Prasad N. Iyer , Yun (Kenneth) Kang , Michael Franti
发明人： Antu K. Dey , John P. Moore , William C. Olson , Sai Prasad N. Iyer , Yun (Kenneth) Kang , Michael Franti
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： This invention provides a modified gp140 envelope polypeptide of an HIV-1 isolate comprising a gp120 polypeptide portion comprising consecutive amino acids and a gp41 ectodomain polypeptide portion comprising consecutive amino acids, said gp41 ectodomain polypeptide portion being modified to comprise isoleucine (I) at an amino acid position equivalent to amino acid position 535; glutamine (Q) at an amino acid position equivalent to amino acid position 543; serine (S) at an amino acid position equivalent to amino acid position 553; lysine (K) at an amino acid position equivalent to amino acid position 567; and arginine (R) at an amino acid position equivalent to amino acid position 588, the amino acid positions being numbered by reference to the HIV-1 isolate KNH1144. This invention also provides nucleic acids encoding such a polypeptide, vectors, host cells, trimeric complexes and compositions thereof. Also provided are antibodies generated against the modified polypeptides and trimeric complexes, and methods of using the modified polypeptides, compositions and trimeric complexes.
摘要翻译： 本发明提供HIV-1分离物的修饰的gp140包膜多肽，其包含包含连续氨基酸的gp120多肽部分和包含连续氨基酸的gp41胞外域多肽部分，所述gp41胞外域多肽部分被修饰为在氨基上包含异亮氨酸（I） 酸性位置相当于氨基酸位置535; 在氨基酸位置543的氨基酸位置处的谷氨酰胺（Q）; 在氨基酸位置553的氨基酸位置处的丝氨酸（S）; 在氨基酸位置567的氨基酸位置处的赖氨酸（K）; 和氨基酸位置等同于氨基酸位置588的氨基酸位置，氨基酸位置通过参考HIV-1分离株KNH1144编号。 本发明还提供了编码这种多肽，载体，宿主细胞，三聚体复合物及其组合物的核酸。 还提供了针对修饰的多肽和三聚体复合物产生的抗体，以及使用修饰的多肽，组合物和三聚体复合物的方法。
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2.发明授权Soluble, stabilized, proteolytically cleaved, trimeric HIV-1 gp140 proteins comprising modifications in the N-terminus of the gp41 ectodomain 失效可溶性，稳定的，蛋白水解切割的三聚体HIV-1 gp140蛋白，其包含gp41胞外域的N末端的修饰公开(公告)号：US07939083B2
公开(公告)日：2011-05-10
申请号：US12312016
申请日：2007-10-17
申请人： Antu K. Dey , John P. Moore , William C. Olson , Sai Prasad N. Iyer , Yun (Kenneth) Kang , Michael Franti
发明人： Antu K. Dey , John P. Moore , William C. Olson , Sai Prasad N. Iyer , Yun (Kenneth) Kang , Michael Franti
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： This invention provides a modified gp140 envelope polypeptide of an HIV-1 isolate comprising a gp120 polypeptide portion comprising consecutive amino acids and a gp41 ectodomain polypeptide portion comprising consecutive amino acids, said gp41 ectodomain polypeptide portion being modified to comprise isoleucine (I) at an amino acid position equivalent to amino acid position 535; glutamine (Q) at an amino acid position equivalent to amino acid position 543; serine (S) at an amino acid position equivalent to amino acid position 553; lysine (K) at an amino acid position equivalent to amino acid position 567; and arginine (R) at an amino acid position equivalent to amino acid position 588, the amino acid positions being numbered by reference to the HIV-1 isolate KNH1144. This invention also provides nucleic acids encoding such a polypeptide, vectors, host cells, trimeric complexes and compositions thereof. Also provided are antibodies generated against the modified polypeptides and trimeric complexes, and methods of using the modified polypeptides, compositions and trimeric complexes.
摘要翻译： 本发明提供HIV-1分离物的修饰的gp140包膜多肽，其包含包含连续氨基酸的gp120多肽部分和包含连续氨基酸的gp41胞外域多肽部分，所述gp41胞外域多肽部分被修饰为在氨基上包含异亮氨酸（I） 酸性位置相当于氨基酸位置535; 在氨基酸位置543的氨基酸位置处的谷氨酰胺（Q）; 在氨基酸位置553的氨基酸位置处的丝氨酸（S）; 在氨基酸位置567的氨基酸位置处的赖氨酸（K）; 和氨基酸位置等同于氨基酸位置588的氨基酸位置，氨基酸位置通过参考HIV-1分离株KNH1144编号。 本发明还提供编码这种多肽，载体，宿主细胞，三聚体复合物及其组合物的核酸。 还提供了针对修饰的多肽和三聚体复合物产生的抗体，以及使用修饰的多肽，组合物和三聚体复合物的方法。
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3.发明申请MODIFIED GP140 ENVELOPE POLYPEPTIDES OF HIV-1 ISOLATES, COMPOSITIONS, STABILIZED TRIMERIC COPLEXES, AND USES THEREOF 失效HIV-1分离体，组合物，稳定的三聚体复合物的改性GP140环糊精及其用途公开(公告)号：US20100041875A1
公开(公告)日：2010-02-18
申请号：US12312016
申请日：2007-10-17
申请人： Antu K. Dey , Moore P. John , William C. Olson , Sai Prasad N. Iyer , Yun (Kenneth) Kang , Michael Franti
发明人： Antu K. Dey , Moore P. John , William C. Olson , Sai Prasad N. Iyer , Yun (Kenneth) Kang , Michael Franti
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： This invention provides a modified gp140 envelope polypeptide of an HIV-1 isolate comprising a gp120 polypeptide portion comprising consecutive amino acids and a gp41 ectodomain polypeptide portion comprising consecutive amino acids, said gp41 ectodomain polypeptide portion being modified to comprise isoleucine (I) at an amino acid position equivalent to amino acid position 535; glutamine (Q) at an amino acid position equivalent to amino acid position 543; serine (S) at an amino acid position equivalent to amino acid position 553; lysine (K) at an amino acid position equivalent to amino acid position 567; and arginine (R) at an amino acid position equivalent to amino acid position 588, the amino acid positions being numbered by reference to the HIV-1 isolate KNH1144. This invention also provides nucleic acids encoding such a polypeptide, vectors, host cells, trimeric complexes and compositions thereof. Also provided are antibodies generated against the modified polypeptides and trimeric complexes, and methods of using the modified polypeptides, compositions and trimeric complexes.
摘要翻译： 本发明提供HIV-1分离物的修饰的gp140包膜多肽，其包含包含连续氨基酸的gp120多肽部分和包含连续氨基酸的gp41胞外域多肽部分，所述gp41胞外域多肽部分被修饰为在氨基上包含异亮氨酸（I） 酸性位置相当于氨基酸位置535; 在氨基酸位置543的氨基酸位置处的谷氨酰胺（Q）; 在氨基酸位置553的氨基酸位置处的丝氨酸（S）; 在氨基酸位置567的氨基酸位置处的赖氨酸（K）; 和氨基酸位置等同于氨基酸位置588的氨基酸位置，氨基酸位置通过参考HIV-1分离株KNH1144编号。 本发明还提供编码这种多肽，载体，宿主细胞，三聚体复合物及其组合物的核酸。 还提供了针对修饰的多肽和三聚体复合物产生的抗体，以及使用修饰的多肽，组合物和三聚体复合物的方法。
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