公开(公告)号：US20180289779A1

公开(公告)日：2018-10-11

申请号：US15833243

申请日：2017-12-06

申请人： Apeiron Biologics AG

发明人： Manfred Schuster ,  Hans Loibner ,  Evelyne Janzek-Hawlat ,  Bernhard Peball ,  Stefan Stranner ,  Bettina Wagner ,  Robert Weik

IPC分类号： A61K38/48 ,  C12N9/64 ,  C12N9/48 ,  C07K14/705 ,  A61K38/00

摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life

公开(公告)号：US20140099297A1

公开(公告)日：2014-04-10

申请号：US14026887

申请日：2013-09-13

申请人： Apeiron Biologics AG

发明人： Manfred Schuster ,  Hans Loibner ,  Evelyne Janzek-Hawlat ,  Bernhard Peball ,  Stefan Stranner ,  Bettina Wagner ,  Robert Weik

IPC分类号： A61K38/48

CPC分类号： A61K38/4813 ,  A61K38/00 ,  C07K14/70596 ,  C12N9/48 ,  C12N9/64

摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life

摘要翻译： 本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。 二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品

公开(公告)号：US10716833B2

公开(公告)日：2020-07-21

申请号：US15833243

申请日：2017-12-06

申请人： Apeiron Biologics AG

发明人： Manfred Schuster ,  Hans Loibner ,  Evelyne Janzek-Hawlat ,  Bernhard Peball ,  Stefan Stranner ,  Bettina Wagner ,  Robert Weik

IPC分类号： G01N33/554 ,  A61K38/48 ,  C07K14/705 ,  C12N9/48 ,  C12N9/64 ,  A61K38/00

摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.