COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF CANCER

    公开(公告)号:US20220112192A1

    公开(公告)日:2022-04-14

    申请号:US17298409

    申请日:2019-11-27

    申请人: ARAXES PHARMA LLC

    摘要: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): (I) or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein A, B, R1, R3, L1, L2, L3, E, A1, A2, A3, A4, G1, G2, W, X, Y, Z, m1, m2, n1, and n2 are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.