公开(公告)号：US20150153345A1

公开(公告)日：2015-06-04

申请号：US14305374

申请日：2014-06-16

申请人： Arbor Vita Corporation

发明人： Eric Dixon ,  Rainer Blaesius ,  Stephen Simkins ,  Steven L. Knapp ,  George Brough ,  Karen Lenz ,  Johannes Schweizer ,  Peter Lu ,  David Garman ,  Jon Silver ,  Charles Mahoney ,  Chamorro Somoza Diaz-Sarmiento

IPC分类号： G01N33/574 ,  G01N33/569 ,  C07K16/08

CPC分类号： G01N33/5748 ,  C07K16/084 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/025 ,  G01N2469/10

摘要： The subject invention provides an antibody composition for detecting E6 protein of at least one HPV strain in a sample. The subject antibodies may be used to detect oncogenic HPV E6 proteins in a sample, and the antibodies find use in a variety of diagnostic and therapeutic applications, including methods of diagnosing and treating cancer. Kits for performing the subject methods and containing the subject antibodies are also provided. Also disclosed in the present invention is a method of generating an antibody that specifically binds to amino-terminus of E6 proteins of at least two HPV strains.

摘要翻译： 本发明提供了用于检测样品中至少一种HPV病毒株的E6蛋白的抗体组合物。 受试抗体可用于检测样品中的致癌HPV E6蛋白，并且抗体可用于多种诊断和治疗应用，包括诊断和治疗癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。 本发明还公开了产生特异性结合至少两种HPV病毒株的E6蛋白的氨基末端的抗体的方法。