公开(公告)号：US20180237780A1

公开(公告)日：2018-08-23

申请号：US15952680

申请日：2018-04-13

Applicant: Arcturus Therapeutics, Inc.

Inventor： Jesper WENGEL

IPC: C12N15/113 ,  C12N15/11 ,  C07H21/00

CPC classification number: C12N15/113 ,  C07H21/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/321 ,  C12N2310/323 ,  C12N2310/3231 ,  C12N2320/51

Abstract: This invention provides UNA oligomers for therapeutics having prolonged stability. The UNA oligomers can be composed of one or more 2′-3′-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers. Embodiments include UNA oligomers with phosphorothioate or boranophosphate intermonomer linkages. The UNA oligomers can be used for therapeutics that target oligonucleotides, nucleic acids, or RNAs to reduce their activity.