公开(公告)号：US12290567B2

公开(公告)日：2025-05-06

申请号：US17011880

申请日：2020-09-03

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar Rajappan ,  Padmanabh Chivukula ,  Kiyoshi Tachikawa ,  Steven Tanis ,  Priya Karmali

IPC: A61K47/54 ,  C07H15/04 ,  C12N15/113

Abstract: ASGP-R binding molecular conjugates are provided. The conjugates are useful to deliver therapeutically effective amounts of biologically active molecules to target cells and tissues of a subject. Compositions are also provided comprising the molecular conjugates.

公开(公告)号：US20240391870A1

公开(公告)日：2024-11-28

申请号：US18660219

申请日：2024-05-09

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar Rajappan ,  Steven Tanis

IPC: C07C333/04 ,  A61K9/51 ,  C07C229/12 ,  C07C237/12 ,  C07C271/22 ,  C07C275/16 ,  C07C327/06 ,  C07D209/24 ,  C07D333/60 ,  C12N15/113

Abstract: The present disclosure describes compounds of Formula (I) and pharmaceutically acceptable salts thereof:

公开(公告)号：US20220378702A1

公开(公告)日：2022-12-01

申请号：US17737862

申请日：2022-05-05

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar Rajappan ,  Steven Tanis ,  Rajesh Mukthavaram ,  Amit Sagi ,  Priya Prakash Karmali ,  Padmanabh Chivukula

IPC: A61K9/127 ,  C07K19/00 ,  A61K31/7105

Abstract: Peptides and Peptide-lipid conjugates are provided in which the peptide has the general Formula (I) wherein, A1 is selected from serine, threonine, O—C1-6 alkyl serine, and O—C1-6 alkyl threonine; A2 is selected from serine, threonine, O—C1-6 alkyl serine, and O—C1-6 alkyl threonine; A3 is selected from glutamic acid, glutamine, asparagine, and aspartic acid; A4 is proline; each A5 is independently selected from a natural or modified amino acid; The peptide-lipid conjugates can be used in lipid formulations for the delivery of nucleic acids.

公开(公告)号：US20220370624A1

公开(公告)日：2022-11-24

申请号：US17737884

申请日：2022-05-05

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar Rajappan ,  Steven Tanis ,  Rajesh Mukthavaram ,  Amit Sagi ,  Priya Prakash Karmali ,  Padmanabh Chivukula

IPC: A61K47/54 ,  A61K47/26 ,  C07K7/04 ,  C07K14/00 ,  C07K19/00 ,  A61P35/00 ,  A61K9/00

Abstract: A lipid composition containing a nucleic acid, wherein the lipid composition comprises a peptide-lipid conjugate, is provided. The peptide of the peptide-lipid conjugates can be from 4 to 52 amino acids in length. Methods of using the lipid composition in the in vivo delivery of nucleic acids are further provided.