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1.发明申请BIOMARKERS FOR DRUG-INDUCED ELONGATED QT INTERVAL AND TORSADES DE POINTES 审中-公开用于药物诱导的长期QT间期和胸苷的生物标志物公开(公告)号：US20110237456A1
公开(公告)日：2011-09-29
申请号：US13070884
申请日：2011-03-24
申请人： Aris FLORATOS , Matthew R. NELSON , Sally L. JOHN
发明人： Aris FLORATOS , Matthew R. NELSON , Sally L. JOHN
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , H01J49/00 , Y10T436/143333
摘要： The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly drug-induced prolonged QT interval or TdP. The invention also provides a method of identifying a subject afflicted with, or at risk of, developing TdP. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing TdP.
摘要翻译： 本发明提供了一种用于预测患者发展不良药物反应，特别是药物诱导的延长QT间期或TdP的风险的方法。 本发明还提供了鉴定患有TdP或正在发展TdP的受试者的方法。 在一些方面，所述方法包括分析至少一种遗传标记，其中所述至少一种遗传标记的存在表明所述受试者患有或具有发展TdP的风险。
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公开(公告)号：US20100120049A1
公开(公告)日：2010-05-13
申请号：US12615944
申请日：2009-11-10
申请人： Aris FLORATOS , Sally L. JOHN , Matthew R. NELSON
发明人： Aris FLORATOS , Sally L. JOHN , Matthew R. NELSON
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly Serious Skin Rash (SSR), including such severe adverse reactions such as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). The invention also provides a method of identifying a subject afflicted with or at risk of developing SSR. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with or at risk of developing SSR. Genetic markers useful in accordance with the methods of the invention are disclosed.
摘要翻译： 本发明提供了一种用于预测患者发生不良药物反应，特别是严重皮疹（SSR）的风险的方法，包括诸如史蒂文生 - 约翰逊综合征（SJS）和毒性表皮坏死松解症（TEN）等严重不良反应。 本发明还提供了鉴定患有或有发展SSR风险的受试者的方法。 在一些方面，所述方法包括分析至少一种遗传标记，其中所述至少一种遗传标记的存在表明所述受试者患有或具有发展SSR的风险。 公开了根据本发明方法有用的遗传标记。
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公开(公告)号：US20100035265A1
公开(公告)日：2010-02-11
申请号：US12505058
申请日：2009-07-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly Drug-Induced Liver Injury (DILI) or hepatotoxicity. The invention also provides a method of identifying a subject afflicted with, or at risk of, developing DILI. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing DILI.
摘要翻译： 本发明提供了一种用于预测患者发生不良药物反应，特别是药物诱导性肝损伤（DILI）或肝毒性的风险的方法。 本发明还提供了鉴定患有DILI或正面临其危险的受试者的方法。 在一些方面，所述方法包括分析至少一种遗传标记，其中所述至少一种遗传标记的存在表明所述受试者患有DILI发生或有风险。
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