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公开(公告)号：US20200277271A1
公开(公告)日：2020-09-03
申请号：US16483644
申请日：2018-02-02
发明人： May KHANNA , Rajesh KHANNA , Vijay GOKHALE , Reena CHAWLA
IPC分类号： C07D401/04 , C07D405/14 , C07D401/14
摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperidinyl-benzoimidazole structure which function as antagonists of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2), and their use as therapeutics for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and/or pain (e.g., neuropathic pain).
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公开(公告)号：US20210371375A1
公开(公告)日：2021-12-02
申请号：US17200444
申请日：2021-03-12
发明人： Laurence HURLEY , Vijay GOKHALE , HyunJin KANG , Kui WU
IPC分类号： C07C275/54 , A61K31/5377 , A61K31/4995 , A61K31/505 , A61K31/17 , A61K31/4402 , C07D401/12 , C07D403/04 , C07D239/34 , C07D239/52 , C07D241/18 , C07D295/088 , A61P35/00 , C07D219/08
摘要： The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula: whereas, n, R1, R2, R3, RH and R12 are as defined herein.
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公开(公告)号：US20190135746A1
公开(公告)日：2019-05-09
申请号：US16315710
申请日：2017-07-07
发明人： Louise HECKER , Vijay GOKHALE , Reena CHAWLA
IPC分类号： C07D209/08 , C07D403/12 , C07D401/12 , C07D417/14 , C07D417/12 , C07D405/12 , A61P11/00
摘要： The present invention relates to a compound of the formula: where n, R and R are those defined herein. The present invention also relates to use of a compound of Formula 1 in treating a clinical condition associated with fibrotic disorder.
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