公开(公告)号：US12180300B2

公开(公告)日：2024-12-31

申请号：US17277828

申请日：2019-09-20

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Youngwook Won ,  David A. Bull ,  Daniel Yongwon Lee

IPC: C07K16/32 ,  A61K47/60 ,  A61K47/68 ,  A61K47/69 ,  A61P35/00

Abstract: Surface-engineered immune cells, such as natural killer cells, grafted with targeting moiety-drug complexes. The present invention combines chemotherapy and immunotherapy by engineering the immune cells to target specific tumor cells through antigen recognition and deliver potent chemotherapeutic agents, thereby destroying the tumor cells. The surface-engineered immune cells may be prepared using a one-step method. The present invention also provides kits for preparing the surface-engineered immune cells.

公开(公告)号：US20240238362A1

公开(公告)日：2024-07-18

申请号：US17917618

申请日：2021-04-06

Applicant: Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Youngwook Won ,  David Bull ,  Minjin Jung ,  Angela Kim

IPC: A61K38/08 ,  A61K38/06 ,  A61P3/04

CPC classification number: A61K38/08 ,  A61K38/06 ,  A61P3/04

Abstract: Provided herein are compositions and methods for treating obesity. In particular, provided herein are anti-obesity peptides and uses of such peptides in the treatment and prevention of obesity and related medical conditions. Further disclosed are the sequences of anti-obesity peptides, wherein the peptides can be cyclized via the addition of a cysteine to each end of the said peptides.