公开(公告)号：US20220280557A1

公开(公告)日：2022-09-08

申请号：US17636209

申请日：2020-09-11

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Abhinav Acharya ,  Joslyn Mangal

IPC: A61K31/765 ,  C12N5/0784 ,  A61K31/4709 ,  A61K39/00 ,  A61K31/501 ,  A61K38/44 ,  A61P37/06

Abstract: The present invention relates to metabolite-based polymers and polymeric particles that serve as therapeutic agents, compositions comprising the same, and methods of use thereof.

公开(公告)号：US20250082571A1

公开(公告)日：2025-03-13

申请号：US18721326

申请日：2022-12-21

Applicant: Arizona Board of Regents on behalf of Arizona State University ,  Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Abhinav Acharya ,  Hsin-Jung (Joyce) Wu

IPC: A61K9/06 ,  A61K38/20 ,  A61K47/34 ,  A61P37/06 ,  C07K16/24

Abstract: The present invention provides a sustained drug release system comprising IL-2 and anti-IL-2 incorporated into a thermosensitive hydrogel that is engineered to be in liquid form at low temperatures for delivery, but form a hydrogel at physiological body temperatures to act as a sustained release platform. The thermostable hydrogel solution slowly releases IL-2 and anti-IL-2 to provide optimal concentrations for effective treatment of autoimmune diseases.

公开(公告)号：US20220411360A1

公开(公告)日：2022-12-29

申请号：US17775372

申请日：2020-11-09

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Abhinav Acharya ,  Kaushal Rege

IPC: C07C53/126 ,  A61K47/69

Abstract: The present invention provides polymers, particles, and compositions thereof that selectively and efficiently deliver various therapeutic agents, such as metabolites, to a cell. The present invention further relates to methods relating to the said polymers, particles, and compositions for enhancing biological tissue growth (e.g. biological tissue regeneration in wound healing) in a subject. The present invention additionally provides kits that find use in the practice of the methods of the invention.

公开(公告)号：US20240191033A1

公开(公告)日：2024-06-13

申请号：US18277731

申请日：2022-02-18

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Abhinav Acharya ,  Arezoo Esrafili

IPC: C08G75/14 ,  A61K31/451 ,  A61K31/795 ,  C08K5/3432

CPC classification number: C08G75/14 ,  A61K31/451 ,  A61K31/795 ,  C08K5/3432 ,  C08G2230/00

Abstract: Disclosed herein are covalent organic frameworks (COFs) comprising dithioacetal linkages, methods of making such COFs, and methods of using the COFs, e.g., for delivery of gases such as nitric oxide and anti-mycobacterial agents such as isoniazid.

公开(公告)号：US20220226499A1

公开(公告)日：2022-07-21

申请号：US17611758

申请日：2020-05-15

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Abhinav Acharya

IPC: A61K47/69 ,  A61K31/194 ,  A61K47/55 ,  A61K9/51 ,  A61L24/04 ,  A61L27/34 ,  A61L27/52 ,  A61L31/10

Abstract: The present disclosure provides metabolite-based polymeric particles and methods for a modulating the intracellular metabolic-profile/pathways. For example, in one aspect, the disclosure relates to alpha-ketoglutarate (aKG)-based polymeric-microparticles and methods of use.