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公开(公告)号：US11931460B2
公开(公告)日：2024-03-19
申请号：US17529930
申请日：2021-11-18
Inventor： Kaushal Rege , Rajeshwar Nitiyanandan , Tanya Nanda
CPC classification number: A61K9/1273 , A61K35/12 , A61K47/6903
Abstract: The instant disclosure is directed to compositions comprising an encapsulated spheroid, and methods of making and using the same. A composition may comprise a spheroid comprising a plurality of cells and aminoglycoside antibiotic-derived hydrogel beads, wherein the spheroid is encapsulated by the aminoglycoside antibiotic-derived hydrogel beads to form an encapsulated spheroid. A method may comprise administering the composition to a subject in need thereof. Another method may comprise administering a compound to the encapsulated spheroid. A method of creating an encapsulated spheroid may comprise coating a surface with an aminoglycoside antibiotic-derived hydrogel, culturing a plurality of cells on the surface, thereby creating a spheroid, and encapsulating the spheroid with a plurality of aminoglycoside antibiotic-derived hydrogel beads.
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公开(公告)号：US10232345B2
公开(公告)日：2019-03-19
申请号：US15547173
申请日：2016-02-12
Inventor： Kaushal Rege , Taraka Sai Pavan Grandhi , Thrimoorthy Potta
Abstract: Methods and materials for the generation of amikacin antibiotic-derived microbeads, (FIG. 3). These beads may function as anion-exchange resins for use in pDNA purification as well as in situ capture of DNA from mammalian cells. New microresin and macroporous monolith based materials also are disclosed and may function for plasmid DNA binding and purification, mammalian whole cell genomic DNA extraction, and in-vitro cell culture.
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3.发明申请公开(公告)号：US20180258416A1
公开(公告)日：2018-09-13
申请号：US15915909
申请日：2018-03-08
Inventor： Kaushal Rege , Kevin Lin , Sudhakar Godeshala Godeshala , Taraka Sai Pavan Grandhi
IPC: C12N15/10 , B01J20/291 , B01D15/38
CPC classification number: C12N15/101 , B01D15/3804 , B01J20/291 , B01J2220/80
Abstract: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
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公开(公告)号：US12251478B2
公开(公告)日：2025-03-18
申请号：US18402138
申请日：2024-01-02
Inventor： Kaushal Rege , Deepanjan Ghosh
IPC: A61K33/242 , A61K9/70 , A61K31/417 , A61K38/18 , A61K38/39 , A61L15/18 , A61L15/20 , A61L15/32 , A61L15/44 , A61L26/00 , A61N5/06 , A61N5/067 , A61P17/02
Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
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5.发明授权公开(公告)号：US10428160B2
公开(公告)日：2019-10-01
申请号：US15645914
申请日：2017-07-10
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , BANNER HEALTH—an Arizona nonprofit corporation
Inventor： Kaushal Rege , Karthik Subramaniam Pushpavanam , Stephen Sapareto
Abstract: An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.
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Patent Agency Ranking
公开(公告)号：US20190133685A1
公开(公告)日：2019-05-09
申请号：US16195121
申请日：2018-11-19
Inventor： Kaushal Rege , Huang-Chiao Huang
IPC: A61B18/20 , A61L24/10 , A61K38/18 , A61K38/19 , A61L24/00 , A61N5/06 , A61K41/00 , A61B18/18 , A61K38/39
Abstract: Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.
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公开(公告)号：US20220071613A1
公开(公告)日：2022-03-10
申请号：US17416240
申请日：2019-12-19
Inventor： Kaushal Rege , Ridha Inam , Yu Yao
Abstract: A method of closing an opening in a tissue comprises providing a light absorbing material, introducing the light absorbing material into a tissue opening, and irradiating the light absorbing material with at least one light source so as to increase a temperature of the light absorbing material, causing the tissue edges of the tissue opening adhere to the light absorbing material and/or to each other. A kit comprising a light absorbing material and a light emitting device is also described.
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公开(公告)号：US10907145B2
公开(公告)日：2021-02-02
申请号：US15915909
申请日：2018-03-08
Inventor： Kaushal Rege , Kevin Lin , Sudhakar Godeshala , Taraka Sai Pavan Grandhi
IPC: C12N15/10 , B01D15/38 , B01J20/291
Abstract: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
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9.发明申请公开(公告)号：US20180066074A1
公开(公告)日：2018-03-08
申请号：US15645914
申请日：2017-07-10
Inventor： Kaushal Rege
CPC classification number: C08B37/0039 , C01G7/00 , C08J3/075 , C08J2305/12 , C08K3/08 , C08K3/30 , C08K5/1535 , C08K2003/0831 , C08K2003/3009 , C08L5/12 , G01J3/00 , G01T1/04
Abstract: An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.
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公开(公告)号：US20240261459A1
公开(公告)日：2024-08-08
申请号：US18402138
申请日：2024-01-02
Inventor： Kaushal Rege , Deepanjan Ghosh
IPC: A61L15/44 , A61K9/70 , A61K31/417 , A61K33/242 , A61K38/18 , A61K38/39 , A61L15/18 , A61L15/20 , A61L15/32 , A61L26/00 , A61N5/06 , A61N5/067 , A61P17/02
CPC classification number: A61L15/44 , A61K9/7007 , A61K31/417 , A61K33/242 , A61K38/1825 , A61K38/39 , A61L15/18 , A61L15/20 , A61L15/32 , A61L26/0004 , A61L26/0066 , A61L26/008 , A61L26/0095 , A61N5/0616 , A61P17/02 , A61L2300/102 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61N5/067
Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent is in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
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