公开(公告)号：US10045990B2

公开(公告)日：2018-08-14

申请号：US15555241

申请日：2016-03-02

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Fernanda Festa ,  Joshua Labaer ,  Jin Park ,  Femina Rauf

IPC: A61K31/519 ,  A61K31/517

Abstract: Disclosed herein are methods of treating diseases that exhibit over-activation of the ERBB4 pathway, such as breast cancer and lung cancer. The method comprises administering to a subject having a disease that exhibits over-activation of the ERBB4 pathway and a gene expression profile consistent with an ERBB4-sensitive profile a therapeutically effective amount of an ERBB4 inhibitor, wherein the disease is effectively treated. Gene expression profiles of ERBB4-sensitive cells and microarrays suitable for protein-tyrosine kinases are also provided.