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公开(公告)号：US11913138B2
公开(公告)日：2024-02-27
申请号：US17405172
申请日：2021-08-18
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C40B30/04 , C12N15/10 , C12Q1/6811
CPC分类号： C40B30/04 , C12N15/1037 , C12N15/1041 , C12N15/1062 , C12Q1/6811 , C12Q1/6811 , C12Q2565/501 , C12Q2565/515
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US20190062728A1
公开(公告)日：2019-02-28
申请号：US15748946
申请日：2016-09-13
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C12N15/10
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US12084727B2
公开(公告)日：2024-09-10
申请号：US18147224
申请日：2022-12-28
IPC分类号： C12Q1/689 , A61K31/437 , A61K35/741 , C12Q1/6883 , G01N33/68
CPC分类号： C12Q1/689 , A61K31/437 , A61K35/741 , C12Q1/6883 , G01N33/6896 , C12Q2600/142 , C12Q2600/158
摘要： The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neurotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the ‘Prevotella-like enterotype’ compared to neurotypical subjects. The relative abundance of genera Prevotella, Coprococcus, Prevotellaceae and Veillonellaceae are significantly lower in autistic children than in neurotypical children. Further, Prevotella, is one of the three main classifiers for the human enterotypes, along with Bacteroides and Ruminococcus. These three core genera are among main contributors in the principle component analysis. ‘Prevotella-like enterotype’ was absent in the autistic group, while neurotypical samples showed an even distribution among the three enterotypes. The present disclosure provides for an understanding the association between gut microbiota, health, and disease states, and provides for potential diagnostic and therapeutic targets.
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公开(公告)号：US20240287708A1
公开(公告)日：2024-08-29
申请号：US18417216
申请日：2024-01-19
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C40B30/04 , C12N15/10 , C12Q1/6811
CPC分类号： C40B30/04 , C12N15/1037 , C12N15/1041 , C12N15/1062 , C12Q1/6811
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US20230220494A1
公开(公告)日：2023-07-13
申请号：US18147224
申请日：2022-12-28
IPC分类号： C12Q1/689 , G01N33/68 , C12Q1/6883 , A61K31/437 , A61K35/741
CPC分类号： C12Q1/689 , G01N33/6896 , C12Q1/6883 , A61K31/437 , A61K35/741 , C12Q2600/142 , C12Q2600/158
摘要： The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neurotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the ‘Prevotella-like enterotype’ compared to neurotypical subjects. The relative abundance of genera Prevotella, Coprococcus, Prevotellaceae and Veillonellaceae are significantly lower in autistic children than in neurotypical children. Further, Prevotella, is one of the three main classifiers for the human enterotypes, along with Bacteroides and Ruminococcus. These three core genera are among main contributors in the principle component analysis. ‘Prevotella-like enterotype’ was absent in the autistic group, while neurotypical samples showed an even distribution among the three enterotypes. The present disclosure provides for an understanding the association between gut microbiota, health, and disease states, and provides for potential diagnostic and therapeutic targets.
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公开(公告)号：US11828753B2
公开(公告)日：2023-11-28
申请号：US17201742
申请日：2021-03-15
发明人： Joshua Labaer , Bharath Takulapalli
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , G01N2440/00
摘要： Described herein are biosensor microarrays comprising detector polypeptide monolayers substantially free of contaminants. Also provided are methods for generation of such biosensor microarrays by capture of polypeptides by arrays comprising capture moieties and associated sensors.
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公开(公告)号：US20210380970A1
公开(公告)日：2021-12-09
申请号：US17405172
申请日：2021-08-18
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C12N15/10 , C12Q1/6811
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US11124791B2
公开(公告)日：2021-09-21
申请号：US15748946
申请日：2016-09-13
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C40B30/04 , C12N15/10 , C12Q1/6811
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US20190004051A1
公开(公告)日：2019-01-03
申请号：US16069111
申请日：2017-01-11
发明人： Joshua Labaer , Ji Qiu , Jie Wang , Garrick Wallstrom , Jin Park , William Rom , Harvey Pass
IPC分类号： G01N33/574
摘要： An immune-proteomic screening of AAb responses using protein arrays has identified two panels of Aab (antigen/antibody complexes) that can potentially differentiate lung adenocarcinoma from smoker controls as well as CT positive benign lung disease. The resulting biomarkers appear to have high specificity so that high risk subjects with a positive CT screen and a positive serum test should get more invasive test such as needle biopsy for a timely cancer diagnosis, among other advantages.
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公开(公告)号：US10045990B2
公开(公告)日：2018-08-14
申请号：US15555241
申请日：2016-03-02
发明人： Fernanda Festa , Joshua Labaer , Jin Park , Femina Rauf
IPC分类号： A61K31/519 , A61K31/517
摘要： Disclosed herein are methods of treating diseases that exhibit over-activation of the ERBB4 pathway, such as breast cancer and lung cancer. The method comprises administering to a subject having a disease that exhibits over-activation of the ERBB4 pathway and a gene expression profile consistent with an ERBB4-sensitive profile a therapeutically effective amount of an ERBB4 inhibitor, wherein the disease is effectively treated. Gene expression profiles of ERBB4-sensitive cells and microarrays suitable for protein-tyrosine kinases are also provided.
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