公开(公告)号：US06754530B2

公开(公告)日：2004-06-22

申请号：US09946495

申请日：2001-09-06

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1365

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在本发明的优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量值，并且调节左心室起搏脉冲的传递时间，以便最佳地同步左心室起搏与右心室 收缩。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06238420B1

公开(公告)日：2001-05-29

申请号：US09564036

申请日：2000-05-04

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1368

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在本发明的优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量值，并且调节左心室起搏脉冲的传递时间，以便最佳地同步左心室起搏与右心室 收缩。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06219579B1

公开(公告)日：2001-04-17

申请号：US09493690

申请日：2000-01-28

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1365

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时机的阻抗测量值，并且调节左心室起搏脉冲的传送时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06223082B1

公开(公告)日：2001-04-24

申请号：US09493689

申请日：2000-01-28

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1365

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量，并且调整左心室起搏脉冲的传递时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06223079B1

公开(公告)日：2001-04-24

申请号：US09493688

申请日：2000-01-28

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1362

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时机的阻抗测量值，并且调节左心室起搏脉冲的传送时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US6070100A

公开(公告)日：2000-05-30

申请号：US990427

申请日：1997-12-15

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量值，并且调节左心室起搏脉冲的传递时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。