公开(公告)号：US20140221370A1

公开(公告)日：2014-08-07

申请号：US14248836

申请日：2014-04-09

Applicant: Array BioPharma Inc.

Inventor： James F. Blake ,  Indrani W. Gunawardana ,  Yvan LeHuerou ,  Peter J. Mohr ,  Eli M. Wallace ,  Bin Wang

IPC: C07D471/04 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/496

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

Abstract: Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。