公开(公告)号：US20060292225A1

公开(公告)日：2006-12-28

申请号：US11424560

申请日：2006-06-16

申请人： Arthur FELIX ,  Robert Martin

发明人： Arthur FELIX ,  Robert Martin

IPC分类号： A61K31/60 ,  A61K9/14

CPC分类号： A61K9/0095 ,  A61K9/143 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1676 ,  A61K31/60

摘要： A water soluble analgesic composition includes a plurality of granules. Each of the granules includes a substrate core and a coating disposed on the substrate core forming an agglomerated product, the coating including a salt of an analgesic, but substantially no particles of a non-salt form of the analgesic. The composition may be created by a method including the steps of: (i) providing a first solution comprising a base, (ii) adding an analgesic to the first solution to create a second solution including a salt of the analgesic, (iii) filtering the second solution to remove residual particles of the analgesic to create a filtered second solution, and (iv) spray drying the filtered second solution onto a substrate to form an agglomerated product having a plurality of granules.

摘要翻译： 水溶性镇痛组合物包含多个颗粒。 每个颗粒包括基材芯和设置在基材芯上的涂层，形成凝聚产物，该涂层包括止痛剂的盐，但基本上没有非盐形式的止痛剂的颗粒。 组合物可以通过包括以下步骤的方法产生：（i）提供包含碱的第一溶液，（ii）向第一溶液中加入止痛剂以产生包含止痛剂的盐的第二溶液，（iii）过滤 第二溶液去除止痛剂的残留颗粒以产生过滤的第二溶液，和（iv）将过滤的第二溶液喷雾干燥到基底上以形成具有多个颗粒的附聚产物。