公开(公告)号：US5816701A

公开(公告)日：1998-10-06

申请号：US691407

申请日：1996-08-02

申请人： Arthur L. Martin ,  Richard S. Earle ,  Warren P. Kerr ,  James L. Martin ,  Ronnie McDowell ,  C. Darryl Morgan

发明人： Arthur L. Martin ,  Richard S. Earle ,  Warren P. Kerr ,  James L. Martin ,  Ronnie McDowell ,  C. Darryl Morgan

IPC分类号： B01F1/00 ,  B01F15/06 ,  G01N13/00 ,  G01N33/15 ,  G01N1/38

CPC分类号： B01F1/0011 ,  B01F1/0027 ,  G01N13/00 ,  G01N33/15 ,  B01F2015/062 ,  B01F2215/0037 ,  G01N2013/006

摘要： In a preferred embodiment, the apparatus includes a dissolution vessel removably seated within an aluminum platen. The apparatus also includes an assembly for automatically measuring a desired volume of media, heating and degassing the volume of media and then dispensing the volume of media into the dissolution vessel. In addition, the apparatus includes a carousel having a plurality of compartments, the carousel being rotatably mounted on a stage, the stage being alignable with the vessel. According to one mode of operation, an open-top, cage-type basket is placed in one or more compartments of the carousel, each basket containing a tablet intended for dissolution. The apparatus additionally includes a shaft aligned with the vessel, the bottom end of the shaft being adapted to frictionally fit together with a basket. The shaft is rotatable and vertically movable so that it can fit together with a basket, pick the basket up out of the carousel, lower the basket into the vessel, rotate the basket within the media and remove the basket from the media. The apparatus further includes a catheter automatically movable in and out of the vessel for sampling the media at desired times, an automated mechanism for loading and replacing a depth filter on the input end of the catheter, an automated mechanism for removing the basket from the end of the shaft after testing has been completed and an automated mechanism for removing media from the vessel after testing has been completed. The apparatus also includes a paddle shaft which may be used interchangeably with the basket shaft if tablets are placed directly in the compartments of the carousel and are then dispensed from the carousel into the vessel through an opening in the bottom of each carousel that is alignable with an opening in the stage.

摘要翻译： 在优选实施例中，该装置包括可移除地位于铝压板内的溶解容器。 该装置还包括用于自动测量所需体积的介质，加热和脱气介质体积，然后将该体积的介质分配到溶解容器中的组件。 此外，该设备包括具有多个隔间的圆盘传送带，该圆盘传送带可旋转地安装在台架上，台架可与容器对准。 根据一种操作模式，开放式笼式篮子被放置在转盘的一个或多个隔室中，每个篮子包含用于溶解的片剂。 该装置还包括与容器对准的轴，该轴的底端适于与篮子摩擦配合。 轴是可旋转的并且可垂直移动，使得其可以与篮子一起装配，将篮子从转盘中取出，将篮子下降到容器中，将篮子旋转在介质内并从介质上移除篮子。 该装置还包括一个自动移动进出容器的导管，用于在期望的时间对介质进行取样，用于在导管的输入端装载和替换深度过滤器的自动化机构，用于从终端移除篮子的自动机构 在完成测试之后，已经完成了用于在测试之后从容器中除去介质的自动化机构。 该设备还包括桨叶杆，如果片剂直接放置在转盘的隔室中，则可以与篮杆轴线互换使用，然后通过每个圆盘传送带底部的开口将圆盘传送带分配到容器中，该转盘可与 在舞台上开幕。