公开(公告)号：US12024559B2

公开(公告)日：2024-07-02

申请号：US17508804

申请日：2021-10-22

Applicant: Asher Biotherapeutics, Inc.

Inventor： Yik Andy Yeung ,  Ivana Djuretic ,  Paul Bessette ,  Wei Chen ,  Sherman Michael Chin ,  Kelly Dare Moynihan ,  Henry C. Nguyen ,  Irene Ni ,  Danielle C. Pappas ,  Terrence Park

IPC: C07K16/28 ,  A61K38/20 ,  A61K47/65 ,  A61K47/68 ,  A61P31/12 ,  A61P35/00

CPC classification number: C07K16/2815 ,  A61K38/2013 ,  A61K47/65 ,  A61K47/6849 ,  A61P31/12 ,  A61P35/00

Abstract: Provided herein are anti-CD8 antigen binding molecules and fusion polypeptides comprising the CD8 antigen binding molecules for selectively modulating the function of CD8+ T cells over other immune cells. In addition, the present disclosure also provides polynucleotides encoding the disclosed antigen binding molecules and fusion polypeptides, and vectors and host cells comprising such polynucleotides. The present disclosure further provides methods for producing the antigen binding molecules and fusion polypeptides, pharmaceutical compositions comprising the same, and uses thereof.