公开(公告)号：US20140242027A1

公开(公告)日：2014-08-28

申请号：US13579399

申请日：2011-02-18

申请人： Ashok Arasappan ,  F. George Njoroge ,  Cecil D. Kwong ,  Subramaniam Ananthan ,  Frank Bennett ,  Francisco Velazquez ,  Vinay Girijavallabhan ,  Yuhua Huang ,  Hollis S. Kezer ,  Joseph Maddry ,  Robert C. REynold ,  Abhijit Roychowdhury ,  Anita T. Fowler ,  John A. Secrist, III ,  Ling Tong ,  Seong Heon Kim ,  Malcolm MacCoss ,  Srikanth Venkatraman ,  vishal Verma

发明人： Ashok Arasappan ,  F. George Njoroge ,  Cecil D. Kwong ,  Subramaniam Ananthan ,  Frank Bennett ,  Francisco Velazquez ,  Vinay Girijavallabhan ,  Yuhua Huang ,  Hollis S. Kezer ,  Joseph Maddry ,  Robert C. REynold ,  Abhijit Roychowdhury ,  Anita T. Fowler ,  John A. Secrist, III ,  Ling Tong ,  Seong Heon Kim ,  Malcolm MacCoss ,  Srikanth Venkatraman ,  vishal Verma

IPC分类号： C07D513/04 ,  C07D417/04 ,  A61K45/06 ,  C07D417/14 ,  C07D491/048 ,  A61K31/506

CPC分类号： A61K31/506 ,  A61K45/06 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D491/048 ,  C07D513/04

摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

摘要翻译： 本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前药，其中R，R 1，X，Y，Z，R 2， R3，R4，R5，R6，R7，R8，R9，R18，R19和n独立选择和如本文所定义。 还提供了包含这些化合物的组合物。 本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。