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公开(公告)号：US20200040101A1
公开(公告)日：2020-02-06
申请号：US16516223
申请日：2019-07-18
发明人： Yuefeng Lu , Kurt Shanebeck , Lu Li , Lei Liu , Shiwen Zhang , Lan Yang , Jian-Feng Lu
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , A61K47/68 , C07K14/765 , C07K14/55 , C07K14/54 , C07K16/28 , A61K31/282 , A61K31/337
摘要： Described and provided herein are novel antibodies for Claudin 18.2. Also described and provided are pharmaceutical compositions of the antibodies and methods of use for the treatment of cancer.
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公开(公告)号：US20230303714A1
公开(公告)日：2023-09-28
申请号：US17991775
申请日：2022-11-21
发明人： Yuefeng Lu , Kurt Shanebeck , Lu Li , Lei Liu , Shiwen Zhang , Lan Yang , Jian-Feng Lu
IPC分类号： C07K16/30 , A61P35/00 , A61K47/68 , C07K14/765 , C07K14/55 , C07K14/54 , C07K16/28 , A61K31/282 , A61K31/337 , A61K39/395
CPC分类号： C07K16/3046 , A61P35/00 , A61K47/6863 , C07K14/765 , C07K14/55 , C07K14/5443 , C07K16/2809 , A61K31/282 , A61K31/337 , A61K39/39558 , C07K2317/31 , C07K2317/565 , C07K2317/24 , C07K2317/732 , C07K2317/734 , A61K2039/505
摘要： Described and provided herein are novel antibodies for Claudin 18.2. Also described and provided are pharmaceutical compositions of the antibodies and methods of use for the treatment of cancer.
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公开(公告)号：US20190106494A1
公开(公告)日：2019-04-11
申请号：US16111158
申请日：2018-08-23
发明人： Aijun Wang , Kurt Shanebeck , Donggou He , Chen Yao , Lu Li , Fang Xia , Yuefeng Lu , Jian-Feng Lu , Lan Yang
摘要： The present invention relates to compositions and methods for immunotherapy of a subject afflicted with diseases such as cancer, an infectious disease, or a neurodegenerative disease, which methods comprise administering to the subject a composition comprising a therapeutically effective amount of an anti-PD-L1 antibody or portion thereof that potentiates an endogenous immune response, either stimulating the activation of the endogenous response or inhibiting the suppression of the endogenous response.
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公开(公告)号：US10077308B2
公开(公告)日：2018-09-18
申请号：US15620771
申请日：2017-06-12
发明人： Aijun Wang , Kurt Shanebeck , Donggou He , Chen Yao , Lu Li , Fang Xia , Yuefeng Lu , Jian-Feng Lu , Lan Yang
CPC分类号： C07K16/2827 , A61K2039/505 , A61P35/00 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/92
摘要： The present invention relates to compositions and methods for immunotherapy of a subject afflicted with diseases such as cancer, an infectious disease, or a neurodegenerative disease, which methods comprise administering to the subject a composition comprising a therapeutically effective amount of an anti-PD-L1 antibody or portion thereof that potentiates an endogenous immune response, either stimulating the activation of the endogenous response or inhibiting the suppression of the endogenous response.
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公开(公告)号：US11505618B2
公开(公告)日：2022-11-22
申请号：US16516223
申请日：2019-07-18
发明人： Yuefeng Lu , Kurt Shanebeck , Lu Li , Lei Liu , Shiwen Zhang , Lan Yang , Jian-Feng Lu
IPC分类号： C07K16/30 , A61P35/00 , A61K47/68 , C07K14/765 , C07K14/55 , C07K14/54 , C07K16/28 , A61K31/282 , A61K31/337 , A61K39/395 , A61K39/00
摘要： Described and provided herein are novel antibodies for Claudin 18.2. Also described and provided are pharmaceutical compositions of the antibodies and methods of use for the treatment of cancer.
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公开(公告)号：US20170355770A1
公开(公告)日：2017-12-14
申请号：US15620771
申请日：2017-06-12
发明人： Aijun Wang , Kurt Shanebeck , Donggou He , Chen Yao , Lu Li , Fang Xia , Yuefeng Lu , Jian-Feng Lu , Lan Yang
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/92
摘要： The present invention relates to compositions and methods for immunotherapy of a subject afflicted with diseases such as cancer, an infectious disease, or a neurodegenerative disease, which methods comprise administering to the subject a composition comprising a therapeutically effective amount of an anti-PD-L1 antibody or portion thereof that potentiates an endogenous immune response, either stimulating the activation of the endogenous response or inhibiting the suppression of the endogenous response.
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公开(公告)号：US20160083444A1
公开(公告)日：2016-03-24
申请号：US14857799
申请日：2015-09-17
申请人： AskGene Pharma, Inc.
发明人： Jian-Feng Lu , Yuefeng Lu , Aijun Wang , Donggou He , Kurt Shanebeck , Chen Yao
IPC分类号： C07K14/505 , C07K16/00
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/30
摘要： The present specification discloses erythropoietin receptor agonists, compositions and medicaments comprising such erythropoietin receptor agonists, methods and uses for such erythropoietin receptor agonists and compositions and medicaments, and methods and uses for erythropoietin receptor agonists and compositions and medicaments for treating an anemia.
摘要翻译： 本说明书公开了促红细胞生成素受体激动剂，包含这种促红细胞生成素受体激动剂的组合物和药物，用于促红细胞生成素受体激动剂及其组合物和药物的方法和用途，以及促红细胞生成素受体激动剂和用于治疗贫血的组合物和药物的方法和用途。
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公开(公告)号：US20190248858A1
公开(公告)日：2019-08-15
申请号：US16399971
申请日：2019-04-30
申请人： AskGene Pharma Inc.
发明人： Jian-Feng Lu , Yuefeng Lu , Aijun Wang , Donggou He , Kurt Shanebeck , Chen Yao
IPC分类号： C07K14/505
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/30
摘要： The present specification discloses erythropoietin receptor agonists, compositions and medicaments comprising such erythropoietin receptor agonists, methods and uses for such erythropoietin receptor agonists and compositions and medicaments, and methods and uses for erythropoietin receptor agonists and compositions and medicaments for treating an anemia.
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公开(公告)号：US10287336B2
公开(公告)日：2019-05-14
申请号：US14857799
申请日：2015-09-17
申请人： AskGene Pharma, Inc.
发明人： Jian-Feng Lu , Yuefeng Lu , Aijun Wang , Donggou He , Kurt Shanebeck , Chen Yao
IPC分类号： C07K14/505 , A61K38/00 , C12N15/62
摘要： The present specification discloses erythropoietin receptor agonists, compositions and medicaments comprising such erythropoietin receptor agonists, methods and uses for such erythropoietin receptor agonists and compositions and medicaments, and methods and uses for erythropoietin receptor agonists and compositions and medicaments for treating an anemia.
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