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1.发明申请公开(公告)号：US20130189683A1
公开(公告)日：2013-07-25
申请号：US13768709
申请日：2013-02-15
申请人： Assistance Publique - Hopitaux De Paris , IGR&D SA , Institut National De La Sante Et De La Recherche Medicale (INSERM) , Institut Gustave-Roussy , Universite De Versailles - St Quentin En Yvelines , Universite Paris-Sud
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12N9/1205 , C12N15/113 , C12Q1/6883 , C12Q2600/156 , G01N33/57426 , G01N33/57496 , G01N2333/91215 , G01N2500/04
摘要： The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
摘要翻译： 本发明涉及蛋白质 - 酪氨酸激酶JAK2的V617F变体，所述变体负责Vaquez Polyglobulia。 本发明还涉及允许其与骨髓增生性疾病相关的红细胞增多症和血小板增多症的第一意图诊断方法，或用于检测骨髓增生性疾病中的JAK2 V617F变体，从而允许其在新的神经学组中重新分类。
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公开(公告)号：US08852931B2
公开(公告)日：2014-10-07
申请号：US13768709
申请日：2013-02-15
申请人： Assistance Publique—Hopitaux de Paris , IGR&D SA , Institut National de la Sante et de la Recherche Medicale (INSERM) , Institut Gustave-Roussy , Universite de Versailles—St Quentin en Yvelines , Universite Paris-Sud
IPC分类号： C12N9/12 , C12N15/63 , C07H21/04 , G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6813 , C12N9/1205 , C12N15/113 , C12Q1/6883 , C12Q2600/156 , G01N33/57426 , G01N33/57496 , G01N2333/91215 , G01N2500/04
摘要： The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
摘要翻译： 本发明涉及蛋白质 - 酪氨酸激酶JAK2的V617F变体，所述变体负责Vaquez Polyglobulia。 本发明还涉及允许其与骨髓增生性疾病相关的红细胞增多症和血小板增多症的第一意图诊断方法，或用于检测骨髓增生性疾病中的JAK2 V617F变体，从而允许其在新的神经学组中重新分类。
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公开(公告)号：US11162100B2
公开(公告)日：2021-11-02
申请号：US16734854
申请日：2020-01-06
申请人： Institut Gustave-Roussy , Institut National de la Sante et de la Recherche Medicale (INSERM) , Assistance Publique—Hopitaux de Paris , Universite de Versailles—St Quentin en Yvelines , Universite Paris—SUD
IPC分类号： C12N15/113 , C12N9/12 , G01N33/574 , C12Q1/6883 , C12Q1/6813
摘要： The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
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公开(公告)号：US10563200B2
公开(公告)日：2020-02-18
申请号：US16424976
申请日：2019-05-29
申请人： Institut Gustave-Roussy , Institut National de la Sante et de la Rescherche Medicale (INSERM) , Assistance Publique—Hopitaux de Paris , Universite de Versailles—St Quentin en Yvelines , Universite Paris—Sud
IPC分类号： C12N15/113 , G01N33/574 , C12Q1/6883 , C12Q1/6813 , C12N9/12
摘要： The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
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公开(公告)号：US20140249204A1
公开(公告)日：2014-09-04
申请号：US14164880
申请日：2014-01-27
申请人： Institut Gustave-Roussy , Institut National De La Sante Et De La Rechereche Scientifique (Inserm) , Universite Paris-Sud , Universite De Versailles - St Quentin En Yvelines , Assistance Publique-Hopitaux De Paris
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6813 , C12N9/1205 , C12N15/113 , C12Q1/6883 , C12Q2600/156 , G01N33/57426 , G01N33/57496 , G01N2333/91215 , G01N2500/04
摘要： The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
摘要翻译： 本发明涉及蛋白质 - 酪氨酸激酶JAK2的V617F变体，所述变体负责Vaquez Polyglobulia。 本发明还涉及允许其与骨髓增生性疾病相关的红细胞增多症和血小板增多症的第一意图诊断方法，或用于检测骨髓增生性疾病中的JAK2 V617F变体，从而允许其在新的神经学组中重新分类。
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公开(公告)号：US10364430B2
公开(公告)日：2019-07-30
申请号：US14164880
申请日：2014-01-27
申请人： Institut Gustave-Roussy , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS , UNIVERSITE DE VERSAILLES—ST QUENTIN EN YVELINES , UNIVERSITE PARIS-SUD
IPC分类号： C12N9/12 , C12N15/113 , C12Q1/6813 , C12Q1/6883 , G01N33/574
摘要： The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
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