专利检索 ap:("Assistance Publique-Hopitaux de Paris" OR "Fondation Imagine-Institut Des Maladies Genetiques" OR "Universtie Paris Descartes" OR "Institut National de la Sante et de la Recherche Medicale (INSERM)") AND inv:"Emmanuelle Six" 第 1 页

1.

发明授权
Method for generating T-cell progenitors 有权

公开(公告)号：US12071635B2

公开(公告)日：2024-08-27

申请号：US15516731

申请日：2015-10-05

申请人： Assistance Publique-Hopitaux de Paris , Fondation Imagine-Institut Des Maladies Genetiques , Universtie Paris Descartes , Institut National de la Sante et de la Recherche Medicale (INSERM)

发明人： Marina Cavazzana , Isabelle André , Chantal Lagresle-Peyrou , Salima Hacein-Bey-Abina , Christian Reimann , Corinne De Chappedelaine , Emmanuelle Six

IPC分类号： C12N5/00 , C12N5/0783

CPC分类号： C12N5/0636 , C12N2501/42 , C12N2502/1114 , C12N2506/11 , C12N2533/50 , C12N2533/52

摘要： The invention relates to the field of cell therapy and to an in vitro method for generating T-cell progenitors, comprising the step of exposing CD34+ cells in a medium containing a Notch ligand, a soluble domain of the Delta-like ligand 4, joined to an Fc region of a protein IgG, in the presence of a fragment of fibronectin comprising the motifs RGDS and CS-1 and a heparin-binding domain.