公开(公告)号：US09428439B2

公开(公告)日：2016-08-30

申请号：US14149450

申请日：2014-01-07

Applicant: Astex Therapeutics Ltd.

Inventor： Martyn Frederickson ,  John Francis Lyons ,  Neil Thomas Thompson ,  Mladen Vinkovic ,  Brian John Williams ,  Andrew James Woodhead ,  Alison Jo-Anne Woolford

IPC: C07D209/44 ,  C07C67/317 ,  C07C67/313 ,  C07C59/08 ,  C07C69/92 ,  C07C235/60

CPC classification number: C07C67/317 ,  C07C59/08 ,  C07C67/313 ,  C07C69/92 ,  C07C235/60 ,  C07D209/44

Abstract: The invention provides an acid addition salt of a compound of the formula (1). Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogs thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analog.

Abstract translation: 本发明提供式（1）化合物的酸加成盐。 本发明还提供制备式（1）化合物及其烷基类似物的方法，用于该方法的新中间体和制备中间体的方法。 本发明还提供式（1）化合物及其乙基类似物的新的医学用途。