公开(公告)号：US5021444A

公开(公告)日：1991-06-04

申请号：US354984

申请日：1989-05-19

申请人： Atsusuke Trada ,  Yoshiya Amemiya ,  Keiichi Matsuda ,  Takeshi Oshima

发明人： Atsusuke Trada ,  Yoshiya Amemiya ,  Keiichi Matsuda ,  Takeshi Oshima

IPC分类号： A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61P7/02 ,  C07D333/54 ,  C07D333/56 ,  C07D333/68 ,  C07D409/06 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D409/06

摘要： Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R.sup.1 and R.sup.2 are hydrogen or alkyl, one of A.sup.1 and A.sup.2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment of prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.