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    Long-term delivery device including loading dose
    1.
    发明授权
    Long-term delivery device including loading dose 失效
    长期输送装置，包括负荷剂量

    公开(公告)号：US5045082A

    公开(公告)日：1991-09-03

    申请号：US463109

    申请日：1990-01-10

    申请人： Atul D. Ayer ,  James B. Eckenhoff ,  Jeremy C. Wright ,  Anthony L. Kuczynski

    发明人： Atul D. Ayer ,  James B. Eckenhoff ,  Jeremy C. Wright ,  Anthony L. Kuczynski

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0068 ,  A61K9/0004

    摘要： The invention provides a long-term dispensing device comprising a first agent delivery means for short-term and continuous delivery of agent, retained together with a second agent delivery means capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (1) a short term delivery means for rapid and continuous delivery of agent to the environment of use; and (2) a long-term delivery means comprising a semipermeable wall which surrounds and defines an internal lumen; a means in the lumen for expanding and occupying an increased volume of the lumen; a beneficial agent in the lumen that provides a dispensable formulation to the environment of use; and a means in the device for delivery of the beneficial agent to the environment of use over time.

    摘要翻译： 本发明提供了一种长期分配装置，其包括用于短期和连续输送药剂的第一药剂递送装置，与能够长期和连续递送药剂的第二药剂递送装置保持在一起。 第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂随时间递送到使用环境中。 随后快速递送有益药剂，其次是持续和长期的药剂输送。 在优选实施例中，该装置包括（1）用于将药剂快速且连续地递送到使用环境的短期递送装置; 和（2）包括围绕并限定内腔的半透壁的长期递送装置; 用于扩张和占据体积增加的管腔中的一种装置; 内腔中的有益剂，为使用环境提供可分配的配方; 以及用于将有益剂递送到使用环境的装置中的装置。