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公开(公告)号：US06960346B2
公开(公告)日：2005-11-01
申请号：US10143144
申请日：2002-05-09
申请人： Atul J. Shukla , James R. Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
发明人： Atul J. Shukla , James R. Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
IPC分类号： A61K9/00 , A61K31/00 , A61K31/65 , A61K47/14 , A61K9/02 , A61F2/02 , A61K9/08 , A61K9/70 , A61K13/02
CPC分类号： A61K9/0024 , A61K9/0012 , A61K9/0043 , A61K9/0048 , A61K31/00 , A61K31/65 , A61K47/14
摘要： A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administration of the pharmaceutical formulation.
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公开(公告)号：US07560120B2
公开(公告)日：2009-07-14
申请号：US11194885
申请日：2005-08-01
申请人： Atul J. Shukla , James R. Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
发明人： Atul J. Shukla , James R. Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61K9/0012 , A61K9/0043 , A61K9/0048 , A61K31/00 , A61K31/65 , A61K47/14
摘要： A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administration of the pharmaceutical formulation.
摘要翻译： 含有一种或多种在一种或多种柠檬酸酯和/或柠檬酸醚的载体中溶解，分散，乳化或悬浮的生物活性物质的制剂。 公开了制备和使用的方法，以及药物制剂的给药试剂盒。
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公开(公告)号：US20050266083A1
公开(公告)日：2005-12-01
申请号：US11194885
申请日：2005-08-01
申请人： Atul Shukla , James Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
发明人： Atul Shukla , James Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
CPC分类号： A61K9/0024 , A61K9/0012 , A61K9/0043 , A61K9/0048 , A61K31/00 , A61K31/65 , A61K47/14
摘要： A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administration of the pharmaceutical formulation.
摘要翻译： 含有一种或多种在一种或多种柠檬酸酯和/或柠檬酸醚的载体中溶解，分散，乳化或悬浮的生物活性物质的制剂。 公开了制备和使用的方法，以及药物制剂的给药试剂盒。
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公开(公告)号：US08349362B2
公开(公告)日：2013-01-08
申请号：US13454235
申请日：2012-04-24
CPC分类号： A61K9/0002 , A61K9/2077 , A61K9/2081 , A61K9/2086 , A61K9/4808 , A61K9/5084 , A61K47/585
摘要： A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.
摘要翻译： 通过在TPTA（Tamper Prone Therapeutic Agent）陷阱的剂型中或其剂型上存在来减少或延缓篡改剂型中所含药物的爆发释放的剂型。 如果剂型未被篡改，则TPTA捕获剂不会显着干扰药物从剂型中释放的速率。 然而，如果剂型已经被物理篡改，则TPTA捕获剂减少或阻止药物从剂型的爆发释放。
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公开(公告)号：US20130095148A1
公开(公告)日：2013-04-18
申请号：US13692117
申请日：2012-12-03
IPC分类号： A61K9/00
CPC分类号： A61K9/0002 , A61K9/2077 , A61K9/2081 , A61K9/2086 , A61K9/4808 , A61K9/5084 , A61K47/585
摘要： A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.
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公开(公告)号：US20080300322A1
公开(公告)日：2008-12-04
申请号：US11809839
申请日：2007-06-01
CPC分类号： A61K47/44
摘要： Compositions containing a vehicle containing a rosin resin or derivative and a non-volatilized solvent or plasticizer. The compositions may be used to deliver a biologically active substance such as an active pharmaceutical ingredient. The concentration of rosin resin or derivative in the vehicle is sufficient to alter the release rate from the composition of a biologically active substance that is dissolved, dispersed, emulsified, or suspended in the vehicle.
摘要翻译： 含有含有松香树脂或衍生物和非挥发性溶剂或增塑剂的载体的组合物。 组合物可用于递送生物活性物质如活性药物成分。 载体中松香树脂或衍生物的浓度足以改变溶解，分散，乳化或悬浮在载体中的生物活性物质的组合物的释放速率。
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公开(公告)号：US20080075669A1
公开(公告)日：2008-03-27
申请号：US11526502
申请日：2006-09-25
IPC分类号： A61K9/44
CPC分类号： A61K9/0002 , A61K9/2077 , A61K9/2081 , A61K9/2086 , A61K9/4808 , A61K9/5084 , A61K47/585
摘要： A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.
摘要翻译： 通过在TPTA（Tamper Prone Therapeutic Agent）陷阱的剂型中或其剂型上存在来减少或延缓篡改剂型中所含药物的爆发释放的剂型。 如果剂型未被篡改，则TPTA捕获剂不会显着干扰药物从剂型中释放的速率。 然而，如果剂型已经被物理篡改，则TPTA捕获剂减少或阻止药物从剂型的爆发释放。
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公开(公告)号：US20120207797A1
公开(公告)日：2012-08-16
申请号：US13454235
申请日：2012-04-24
IPC分类号： A61K9/00 , A61P25/04 , A61P25/36 , A61K31/485
CPC分类号： A61K9/0002 , A61K9/2077 , A61K9/2081 , A61K9/2086 , A61K9/4808 , A61K9/5084 , A61K47/585
摘要： A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.
摘要翻译： 通过在TPTA（Tamper Prone Therapeutic Agent）陷阱的剂型中或其剂型上存在来减少或延缓篡改剂型中所含药物的爆发释放的剂型。 如果剂型未被篡改，则TPTA捕获剂不会显着干扰药物从剂型中释放的速率。 然而，如果剂型已经被物理篡改，则TPTA捕获剂减少或阻止药物从剂型的爆发释放。
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公开(公告)号：US08187636B2
公开(公告)日：2012-05-29
申请号：US11526502
申请日：2006-09-25
CPC分类号： A61K9/0002 , A61K9/2077 , A61K9/2081 , A61K9/2086 , A61K9/4808 , A61K9/5084 , A61K47/585
摘要： A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.
摘要翻译： 通过在TPTA（Tamper Prone Therapeutic Agent）陷阱的剂型中或其剂型上存在来减少或延缓篡改剂型中所含药物的爆发释放的剂型。 如果剂型未被篡改，则TPTA捕获剂不会显着干扰药物从剂型中释放的速率。 然而，如果剂型已经被物理篡改，则TPTA捕获剂减少或阻止药物从剂型的爆发释放。
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公开(公告)号：US20100099696A1
公开(公告)日：2010-04-22
申请号：US12587771
申请日：2009-10-13
申请人： Anthony Edward Soscia , Yingxu Peng , Yichun Sun , James R. Johnson , Atul J. Shukla , Wen Qu
发明人： Anthony Edward Soscia , Yingxu Peng , Yichun Sun , James R. Johnson , Atul J. Shukla , Wen Qu
IPC分类号： A61K47/32 , A61K47/26 , A61K31/485 , A61P25/36
CPC分类号： A61K31/44 , A61K9/1635 , A61K9/2027 , A61K9/2086 , A61K9/4866
摘要： Oral dosage form containing a therapeutically effective amount of a drug susceptible to abuse and an effective amount of an embolizing agent which causes the production of a solid or semi-solid embolus or blockage after tampering.
摘要翻译： 含有治疗有效量的易于滥用的药物和有效量的栓塞剂的口服剂型，其导致在篡改后产生固体或半固体栓塞或堵塞。
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