公开(公告)号：US20060154276A1

公开(公告)日：2006-07-13

申请号：US11293616

申请日：2005-12-01

申请人： Augusto Lois ,  Bruce Neri ,  Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

发明人： Augusto Lois ,  Bruce Neri ,  Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

IPC分类号： C12Q1/68 ,  G01N33/569 ,  G01N33/53

CPC分类号： G01N33/6854 ,  G01N33/6893 ,  G01N2800/065 ,  G01N2800/52

摘要： The present invention provides methods for diagnosing inflammatory bowel disease (IBD) or for differentiating between Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC) in an individual by using a combination of learning statistical classifiers based upon the presence or level of one or more IBD markers in a sample from the individual. The present invention also provides methods for diagnosing the presence or severity of IBD and for stratifying IBD in an individual by determining the level of one or more IBD markers in a sample from the individual and calculating an index value using an algorithm based upon the level of the IBD markers. Methods for monitoring the efficacy of IBD therapy, monitoring the progression or regression of IBD, and optimizing therapy in an individual having IBD are also provided.

摘要翻译： 本发明提供了通过使用基于存在的学习统计分类器的组合来诊断炎症性肠病（IBD）或用于区分个体中的克罗恩病（CD），溃疡性结肠炎（UC）和不确定性结肠炎（IC） 或来自个体的样品中的一种或多种IBD标记物的水平。 本发明还提供了用于诊断IBD的存在或严重性以及通过确定来自个体的样本中的一种或多种IBD标记的水平来计算个体中IBD的分级的方法，并且使用基于 IBD标记。 还提供了用于监测IBD治疗的功效，监测IBD的进展或消退以及优化IBD个体治疗的方法。

公开(公告)号：US20060003392A1

公开(公告)日：2006-01-05

申请号：US11128011

申请日：2005-05-11

申请人： Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

发明人： Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

IPC分类号： G01N33/53 ,  G01N33/569

CPC分类号： G01N33/6893 ,  G01N2800/065 ,  G01N2800/52

摘要： The present invention provides methods for diagnosing the presence or severity of inflammatory bowel disease (IBD) in an individual and methods for stratifying IBD by determining the level of one or more IBD markers in a sample from the individual and calculating an index value using an algorithm based upon the level of the IBD markers. Methods for monitoring the efficacy of IBD therapy, monitoring the progression or regression of IBD, and optimizing therapy in an individual having IBD are also provided.

摘要翻译： 本发明提供用于诊断个体中炎症性肠病（IBD）的存在或严重性的方法以及通过确定来自个体的样品中的一种或多种IBD标记物的水平来分级IBD的方法，并使用算法计算指数值 基于IBD标记的水平。 还提供了用于监测IBD治疗的功效，监测IBD的进展或消退以及优化IBD个体治疗的方法。