公开(公告)号：US11801364B2

公开(公告)日：2023-10-31

申请号：US16624986

申请日：2018-06-29

Applicant: Avectas Limited

Inventor： Michael Maguire ,  Shane Finnegan

IPC: A61M25/01 ,  A61M25/00 ,  B05B5/00 ,  B05B5/16 ,  A61M25/06 ,  A61M25/09

CPC classification number: A61M25/0122 ,  A61M25/0043 ,  A61M25/0068 ,  A61M25/0074 ,  B05B5/007 ,  B05B5/165 ,  A61M2025/0057 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09133 ,  A61M2205/0233 ,  A61M2205/3334 ,  A61M2210/1039

Abstract: An apparatus includes a catheter, and an electrode and methods of delivering molecules to eukaryotic cells using such an apparatus. The catheter defines a fluidic channel and has a distal opening. The electrode is within the fluidic channel and is spaced a distance from the distal opening of the catheter. The catheter is arranged to prevent direct contact between any electrode of the apparatus and tissue. Related apparatus, systems, techniques and articles are also described.

公开(公告)号：US20200215307A1

公开(公告)日：2020-07-09

申请号：US16624986

申请日：2018-06-29

Applicant: Avectas Limited

Inventor： Michael Maguire ,  Shane Finnegan

IPC: A61M25/01 ,  A61M25/00 ,  B05B5/00 ,  B05B5/16

Abstract: An apparatus includes a catheter, and an electrode and methods of delivering molecules to eukaryotic cells using such an apparatus. The catheter defines a fluidic channel and has a distal opening. The electrode is within the fluidic channel and is spaced a distance from the distal opening of the catheter. The catheter is arranged to prevent direct contact between any electrode of the apparatus and tissue. Related apparatus, systems, techniques and articles are also described.

公开(公告)号：US20240263123A1

公开(公告)日：2024-08-08

申请号：US18393936

申请日：2023-12-22

Applicant: Avectas Limited

Inventor： Alan Patrick Pearson ,  Shane Finnegan ,  Simon Peter Cox ,  Rishi Dhanvantray Jobanputra ,  Donal Joseph Taylor ,  Franck Joseph Dorien Rubiconi

IPC: C12M1/00 ,  G01N1/38

CPC classification number: C12M29/06 ,  G01N1/38 ,  G01N2001/387

Abstract: An apparatus is provided. The apparatus can include a housing having a first end and a second end. The first end can include a sample inlet and a gas inlet. The second end can include a sample outlet and a gas outlet. The apparatus can also include a sample delivery passage extending within the housing and fluidically coupling the sample inlet to the sample outlet. The apparatus can also include a gas delivery passage extending within the housing and fluidically coupling the gas inlet to the gas outlet. Systems and methods including the apparatus are also provided herein.

公开(公告)号：US20200232121A1

公开(公告)日：2020-07-23

申请号：US16624997

申请日：2018-06-22

Applicant: Avectas Limited

Inventor： Shane Finnegan ,  Gillian Hendy ,  Michael Maguire

IPC: D01D5/00 ,  D01D5/084

Abstract: Systems, devices, and methods for electro spinning are provided. For example, a system includes a collector including load sensors attached thereto, the collector configured to receive an extruded polymer; and an electro spinning melt head assembly positioned above the collector and configured to extrude the polymer. The electro spinning melt head assembly and/or the collector is configured to move. The melt head assembly includes a syringe assembly and at least one heating element configured to supply heat to the syringe assembly. The syringe assembly includes: a syringe including a passage extending from a proximal end, the passage configured to receive the polymer, and a nozzle configured to allow polymer to pass therethrough.

公开(公告)号：US20190217315A1

公开(公告)日：2019-07-18

申请号：US16329407

申请日：2017-08-31

Applicant: Avectas Limited

Inventor： Michael Maguire ,  Shane Finnegan

IPC: B05B5/00 ,  B05B5/025 ,  B05B12/08 ,  B05B12/18 ,  C12N11/08 ,  A61K9/50

CPC classification number: B05B5/006 ,  A61K9/5089 ,  B05B1/14 ,  B05B1/26 ,  B05B5/0255 ,  B05B12/082 ,  B05B12/18 ,  C12N11/08

Abstract: The current subject matter includes an adaptive electrospray device that creates consistent output when operating in atmosphere (e.g., not a vacuum). For example, the current subject matter includes an adaptive system that can monitor two current reference points (at the emitter and counter-electrode, respectively), determine a change in emitter current that will account for the parasitic losses, and adjust the emitter current accordingly. In addition, the current subject matter includes a high-throughput adaptive electrospray device having an array of emitters that rapidly switches the electrical potential of different emitters in an array on and off at a predetermined sequence that mitigates or eliminates interference from neighboring emitters. Related apparatus, systems, techniques and articles are also described.