公开(公告)号：US11642244B2

公开(公告)日：2023-05-09

申请号：US16987370

申请日：2020-08-06

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

CPC classification number: A61F9/008 ,  A61F2009/00844 ,  A61F2009/00872 ,  A61F2009/00897

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

公开(公告)号：US20210038428A1

公开(公告)日：2021-02-11

申请号：US16987370

申请日：2020-08-06

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

公开(公告)号：US20220106298A1

公开(公告)日：2022-04-07

申请号：US17424413

申请日：2020-01-24

Applicant: Avedro, Inc.

Inventor： Jason Hill ,  Desmond Adler

IPC: C07D403/12 ,  A61P27/10 ,  C07D403/14 ,  C07D401/14 ,  C07D229/02

Abstract: This disclosure features bis(diazirine) derivatives of the formulae (I) (1-a) or (1-b) that generate cross-linking in the cornea in response to exposure to an electromagnetic irradiation (e.g. UV-light). The compounds are useful, e.g. for treating a subject (e.g. a human) having a disease, disorder or condition in which abnormal shaping of the cornea (e.g. thinning of the cornea, e.g. bilateral thinning of the cornea, e.g. bilateral thinning of the central, paracentral, or peripheral cornea, or steepening (e.g., bulging) of the cornea) contributes to the pathology and/or symptoms, and/or progression of the disease, disorder or condition. Examples of such diseases, disorders or conditions include: (i) corneal ectatic disorders; (ii) vision conditions; and (iii) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular examples of such diseases, disorders or conditions include keratoconus, keratoglobus, pellucid marginal degeneration, corneal ectasia (e.g. postoperative ectasia, e.g. post-LASIK ectasia), Terrien's marginal degeneration, myopia, hyperopia, astigmatism, irregular astigmatism and presbyopia. In some embodiments, the claimed methods can be performed in the absence of added or supplemental oxygen levels, which can be advantageous in some applications. Preferred exemplary compounds are e.g. bis(diazirine) amino acid derivatives, such as e.g. example 1:

公开(公告)号：US20230346601A1

公开(公告)日：2023-11-02

申请号：US18313078

申请日：2023-05-05

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

CPC classification number: A61F9/008 ,  A61F2009/00844 ,  A61F2009/00897 ,  A61F2009/00872

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

公开(公告)号：US20250161114A1

公开(公告)日：2025-05-22

申请号：US19030052

申请日：2025-01-17

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.