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1.发明申请Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents 有权复杂混合物中蛋白质在水性溶剂中储存期间稳定化的方法公开(公告)号：US20040230038A1
公开(公告)日：2004-11-18
申请号：US10796160
申请日：2004-03-10
IPC分类号： C07K014/195 , C07K014/435
CPC分类号： C07K14/62 , C07K2319/00
摘要： The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous proteins in microorganisms.
摘要翻译： 本发明涉及在水溶液中储存蛋白质的方法。 半胱氨酸的添加延迟了蛋白质有效浓度的时间下降。 该方法适用于生产微生物中的异源蛋白质。
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2.发明申请Process for obtaining insulin precursors having correctly bonded cystine bridges 有权获得具有正确结合的胱氨酸桥的胰岛素前体的方法公开(公告)号：US20020156234A1
公开(公告)日：2002-10-24
申请号：US09947563
申请日：2001-09-07
IPC分类号： C07K014/62
摘要： The present invention relates to an improved process for obtaining a precursor of an insulin or insulin derivative having correctly bonded cystine bridges in the presence of cysteine or cysteine hydrochloride and chaotropic auxiliary.
摘要翻译： 本发明涉及在半胱氨酸或半胱氨酸盐酸盐和离液序列辅助剂的存在下获得具有正确键合的胱氨酸桥的胰岛素或胰岛素衍生物的前体的改进方法。
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3.发明申请Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents 有权复杂混合物中蛋白质在水性溶剂中储存期间稳定化的方法公开(公告)号：US20020058623A1
公开(公告)日：2002-05-16
申请号：US09991964
申请日：2001-11-26
IPC分类号： A61K038/28 , C12P021/02
CPC分类号： C07K14/62 , C07K2319/00
摘要： The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous proteins in microorganisms.
摘要翻译： 本发明涉及在水溶液中储存蛋白质的方法。 半胱氨酸的添加延迟了蛋白质有效浓度的时间下降。 该方法适用于生产微生物中的异源蛋白质。
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